VX-745
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- $27 - $5500
- Product name: VX-745
- CAS: 209410-46-8
- MF: C19H9Cl2F2N3OS
- MW: 436.26
- EINECS:
- MDL Number:MFCD09834070
- Synonyms:6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]- (9CI);6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]-;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylsulfanyl)-6H-pyriMido[3,4-b]pyridazin-6-one;VX-745(VX 745);5-(2,6-Dichloro-phenyl)-2-(2,4-difluoro-phenylsulfanyl)-1,7,8a-triaza-naphthalen-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one VX-745
37 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemcia Scientific
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 2x5mg
- 10mg
- 25mg
- 50mg
- 250mg
- 500mg
- 1g
- 2g
- 5G
- 10g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3754-M010
- Product descriptionVX-745 ≥95%
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1123
- Product descriptionVX745
- Packaging1mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1123
- Product descriptionVX745
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189058
- Product descriptionVX-745 98+%
- Packaging5mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189058
- Product descriptionVX-745 98+%
- Packaging10mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189058
- Product descriptionVX-745 98+%
- Packaging50mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189058
- Product descriptionVX-745 98+%
- Packaging1g
- Price$2370
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8686
- Product descriptionVX-745
- Packaging50mg
- Price$434
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0180
- Product descriptionVX-745
- Packaging5mg
- Price$73
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0180
- Product descriptionVX-745
- Packaging10mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0180
- Product descriptionVX-745
- Packaging50mg
- Price$312
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS469813
- Product descriptionVX-745
- Packaging50mg
- Price$317
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1811
- Product descriptionVX745 99%
- Packaging2x5mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD139233
- Product description5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one
- Packaging500mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD139233
- Product description5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one
- Packaging1g
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD139233
- Product description5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one
- Packaging2g
- Price$1600
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3754-M010 | VX-745 ≥95% | 10mg | $140 | 2021-12-16 | Buy |
| AK Scientific | SYN1123 | VX745 | 1mg | $100 | 2021-12-16 | Buy |
| AK Scientific | SYN1123 | VX745 | 50mg | $640 | 2021-12-16 | Buy |
| Ambeed | A189058 | VX-745 98+% | 5mg | $75 | 2021-12-16 | Buy |
| Ambeed | A189058 | VX-745 98+% | 10mg | $126 | 2021-12-16 | Buy |
| Ambeed | A189058 | VX-745 98+% | 50mg | $320 | 2021-12-16 | Buy |
| Ambeed | A189058 | VX-745 98+% | 1g | $2370 | 2021-12-16 | Buy |
| ApexBio Technology | A8686 | VX-745 | 50mg | $434 | 2021-12-16 | Buy |
| Apolloscientific | BISN0180 | VX-745 | 5mg | $73 | 2021-12-16 | Buy |
| Apolloscientific | BISN0180 | VX-745 | 10mg | $124 | 2021-12-16 | Buy |
| Apolloscientific | BISN0180 | VX-745 | 50mg | $312 | 2021-12-16 | Buy |
| Arctom | AS469813 | VX-745 | 50mg | $317 | 2021-12-16 | Buy |
| Axon Medchem | Axon1811 | VX745 99% | 2x5mg | $154 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139233 | 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one | 500mg | $550 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139233 | 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one | 1g | $900 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139233 | 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one | 2g | $1600 | 2021-12-16 | Buy |
Properties
Melting point :261-264 °C
Boiling point :578.9±60.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥21.8 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH with gentle warming and ultrasonic
form :powder
pka :-0.97±0.40(Predicted)
color :white to beige
Boiling point :578.9±60.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥21.8 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH with gentle warming and ultrasonic
form :powder
pka :-0.97±0.40(Predicted)
color :white to beige
Safety Information
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Description
p38α is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases. It is widely expressed in endothelial, immune, and inflammatory cells and plays a central role in the regulation of proinflammatory cytokine production including TNF-α, IL-1β, and IL-6. VX-745 is a potent inhibitor of p38α MAPK (IC50 = 10 nM) with 20-fold selectivity over p38β and 1000-fold selectivity over closely related kinases, ERK1 and JNK1-3. It blocks IL-1β and TNF-α release in whole blood in vitro with IC50 values of 150 and 180 nM, respectively. VX-745 has been shown to demonstrate anti-inflammatory efficacy in an animal model of rheumatoid arthritis, but was discontinued in clinical trial due to adverse central nervous system effects.More related product prices
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Suppliers and manufacturers
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Shandong chuangyingchemical Co., Ltd.
Alchem Pharmtech,Inc.
CONIER CHEM AND PHARMA LIMITED
Xi'an Yutbon Pharmaceutical Technology Co., Ltd
Unipharm pharmaceutical industry Co., Ltd
Dayang Chem (Hangzhou) Co.,Ltd.
Zhejiang J&C Biological Technology Co.,Limited
