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ChemicalBook >> CAS DataBase List >> Pimodivir

Pimodivir

Pimodivir price.
  • $90 - $2700
  • Product name: Pimodivir
  • CAS: 1629869-44-8
  • MF: C20H19F2N5O2
  • MW: 399.39
  • EINECS:
  • MDL Number:MFCD31382121
  • Synonyms:Pimodivir;Pimodivir (VX-787);VX-787;VRT0928787;VRT-0928787;VX-787; VX 787; VX787; JNJ-872; JNJ 872; JNJ872; VRT-0928787; VRT 0928787; VRT0928787;PIMODIVIR;VX-787 (Pimodivir);Bicyclo[2.2.2]octane-2-carboxylic acid, 3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-, (2S,3S)-
9 prices
Selected condition:
Brand
  • AHH
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 1g
  • ManufacturerAHH
  • Product numberAPI-1946
  • Product descriptionVX787 VX787
  • Packaging1g
  • Price$2300
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29321
  • Product descriptionPimodivir
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29321
  • Product descriptionPimodivir
  • Packaging10mg
  • Price$146
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29321
  • Product descriptionPimodivir
  • Packaging25mg
  • Price$343
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6423
  • Product descriptionPimodivir 99.45%
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6423
  • Product descriptionPimodivir 99.45%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6423
  • Product descriptionPimodivir 99.45%
  • Packaging25mg
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9815
  • Product descriptionPimodivir(VX-787) >98%
  • Packaging1g
  • Price$2700
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberP447815
  • Product descriptionPimodivir
  • Packaging10mg
  • Price$140
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1946 VX787 VX787 1g $2300 2021-12-16 Buy
Cayman Chemical 29321 Pimodivir 5mg $93 2024-03-01 Buy
Cayman Chemical 29321 Pimodivir 10mg $146 2024-03-01 Buy
Cayman Chemical 29321 Pimodivir 25mg $343 2024-03-01 Buy
ChemScene CS-6423 Pimodivir 99.45% 5mg $90 2021-12-16 Buy
ChemScene CS-6423 Pimodivir 99.45% 10mg $150 2021-12-16 Buy
ChemScene CS-6423 Pimodivir 99.45% 25mg $270 2021-12-16 Buy
DC Chemicals DC9815 Pimodivir(VX-787) >98% 1g $2700 2021-12-16 Buy
TRC P447815 Pimodivir 10mg $140 2021-12-16 Buy

Properties

Density :1.501±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO, not in water:100.0(Max Conc. mg/mL);250.38(Max Conc. mM)
form :A solid
pka :4.32±0.40(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2; KD = <0.003 μM). It also binds to glycogen synthase kinase 3β (GSK3β; Ki = ~1.6 μM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = <0.15-2.8 nM in a cell-based assay). It increases the antiviral activity of oseltamivir , zanamivir , and favipiravir (T-705; ) with 50% combination index (CI50) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay. Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.

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