SGX-523
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- $44 - $4050
- Product name: SGX-523
- CAS: 1022150-57-7
- MF: C18H13N7S
- MW: 359.41
- EINECS:-0
- MDL Number:MFCD16660190
- Synonyms:SGX-523;6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline;SGX 523(SGX-523);Quinoline,6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-;6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline SGX 523;SGX-523, >=98%;6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline;SGX-523;SGX523; SGX 523
36 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 2mg
- 5mg
- 1MG
- 50
- 10
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1000mg
- 1g
- 10g
- ManufacturerAK Scientific
- Product numberX7475
- Product descriptionSGX-523
- Packaging25mg
- Price$345
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7475
- Product descriptionSGX-523
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000484
- Product descriptionSGX-523 95.00%
- Packaging1MG
- Price$148.05
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000484
- Product descriptionSGX-523 95.00%
- Packaging50MG
- Price$1552.32
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1196
- Product descriptionSGX-523
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60247
- Product descriptionSGX-523
- Packaging10mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181144
- Product descriptionSGX-523 >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181144
- Product descriptionSGX-523 >98%
- Packaging1000mg
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM32803
- Product descriptionSGX 523
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM32803
- Product descriptionSGX 523
- Packaging50mg
- Price$438
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18093
- Product descriptionSGX523 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18093
- Product descriptionSGX523 ≥98%
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18093
- Product descriptionSGX523 ≥98%
- Packaging10mg
- Price$278
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18093
- Product descriptionSGX523 ≥98%
- Packaging25mg
- Price$533
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM144194
- Product description6-(6-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio)quinoline 98%
- Packaging50mg
- Price$352
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0154
- Product descriptionSGX-523 99.28%
- Packaging2mg
- Price$72
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7475 | SGX-523 | 25mg | $345 | 2021-12-16 | Buy |
| AK Scientific | X7475 | SGX-523 | 50mg | $540 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000484 | SGX-523 95.00% | 1MG | $148.05 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000484 | SGX-523 95.00% | 50MG | $1552.32 | 2021-12-16 | Buy |
| ApexBio Technology | A1196 | SGX-523 | 5mg | $120 | 2021-12-16 | Buy |
| Arctom | CFN60247 | SGX-523 | 10mg | $138 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181144 | SGX-523 >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181144 | SGX-523 >98% | 1000mg | $2691.1 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM32803 | SGX 523 | 10mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM32803 | SGX 523 | 50mg | $438 | 2021-12-16 | Buy |
| Cayman Chemical | 18093 | SGX523 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18093 | SGX523 ≥98% | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 18093 | SGX523 ≥98% | 10mg | $278 | 2024-03-01 | Buy |
| Cayman Chemical | 18093 | SGX523 ≥98% | 25mg | $533 | 2024-03-01 | Buy |
| Chemenu | CM144194 | 6-(6-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio)quinoline 98% | 50mg | $352 | 2021-12-16 | Buy |
| ChemScene | CS-0154 | SGX-523 99.28% | 2mg | $72 | 2021-12-16 | Buy |
Properties
Density :1.485
storage temp. :Store at -20°C
solubility :≥17.95 mg/mL in DMSO
pka :3.94±0.10(Predicted)
form :solid
color :Light yellow to yellow
storage temp. :Store at -20°C
solubility :≥17.95 mg/mL in DMSO
pka :3.94±0.10(Predicted)
form :solid
color :Light yellow to yellow
Safety Information
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Description
The hepatocyte growth factor receptor c-Met commonly shows elevated activity in several forms of cancer. SGX523 is a potent, selective, ATP-competitive inhibitor that blocks the tyrosine kinase activity of c-Met with an IC50 value of 4 nM. It is over 1,000-fold selective for c-Met over a panel of other kinases. SGX523 is orally active and dose-dependently inhibits the growth of a variety of tumor xenografts in mice. The effectiveness of SGX523 is enhanced when combined with other chemotherapeutic compounds, including inhibitors of EGFR. SGX523 is metabolized, at least in part, by aldehyde oxidase, an enzyme that differs in activity across different species.Related product price
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