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ChemicalBook >> CAS DataBase List >> Ivacaftor

Ivacaftor

Ivacaftor price.
  • $28 - $25200
  • Product name: Ivacaftor
  • CAS: 873054-44-5
  • MF: C24H28N2O3
  • MW: 392.49
  • EINECS:-0
  • MDL Number:MFCD17171361
  • Synonyms:Ivacaftor, >=98%;3-QuinolinecarboxaMide, N-[2,4-bis(1,1-diMethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-;N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide;VX 770, Ivacaftor;Ivacaftor-D4;VX-770(Ivacattor);IVACAFTOR (VX-770);VX 770;N-(2,4-DITERT-BUTYL-5-HYDROXYPHENYL)-4-OXO-1H-QUINOLINE-3-CARBOXAMIDE
32 prices
Selected condition:
Brand
  • AccelPharmtech
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1unit
  • 1MG
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • 500G
  • 1KG
  • 10mM(in 1mL DMSO)
  • ManufacturerAccelPharmtech
  • Product numberXP2372
  • Product descriptionVX-770 99.00%
  • Packaging500G
  • Price$14700
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberXP2372
  • Product descriptionVX-770 99.00%
  • Packaging1KG
  • Price$25200
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ97241
  • Product descriptionIvacaftor(VX-770)
  • Packaging250mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0007687
  • Product descriptionVX-770 95.00%
  • Packaging5MG
  • Price$497.12
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0007687
  • Product descriptionVX-770 95.00%
  • Packaging1MG
  • Price$148.05
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5047
  • Product descriptionIvacaftor(VX-770)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5047
  • Product descriptionIvacaftor(VX-770)
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5047
  • Product descriptionIvacaftor(VX-770)
  • Packaging25mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5047
  • Product descriptionIvacaftor(VX-770)
  • Packaging10mM(in 1mL DMSO)
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5047
  • Product descriptionIvacaftor(VX-770)
  • Packaging100mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60053
  • Product descriptionIvacaftor(VX-770) ≥98%
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFI143182
  • Product descriptionIvacaftor
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFI143182
  • Product descriptionIvacaftor
  • Packaging50mg
  • Price$332.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15145
  • Product descriptionIvacaftor ≥98%
  • Packaging1mg
  • Price$33
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15145
  • Product descriptionIvacaftor ≥98%
  • Packaging5mg
  • Price$131
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15145
  • Product descriptionIvacaftor ≥98%
  • Packaging10mg
  • Price$245
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech XP2372 VX-770 99.00% 500G $14700 2021-12-16 Buy
AccelPharmtech XP2372 VX-770 99.00% 1KG $25200 2021-12-16 Buy
AK Scientific J97241 Ivacaftor(VX-770) 250mg $130 2021-12-16 Buy
American Custom Chemicals Corporation API0007687 VX-770 95.00% 5MG $497.12 2021-12-16 Buy
American Custom Chemicals Corporation API0007687 VX-770 95.00% 1MG $148.05 2021-12-16 Buy
ApexBio Technology A5047 Ivacaftor(VX-770) 1unit $28 2021-12-16 Buy
ApexBio Technology A5047 Ivacaftor(VX-770) 5mg $50 2021-12-16 Buy
ApexBio Technology A5047 Ivacaftor(VX-770) 25mg $80 2021-12-16 Buy
ApexBio Technology A5047 Ivacaftor(VX-770) 10mM(in 1mL DMSO) $80 2021-12-16 Buy
ApexBio Technology A5047 Ivacaftor(VX-770) 100mg $135 2021-12-16 Buy
Arctom CFN60053 Ivacaftor(VX-770) ≥98% 10mg $108 2021-12-16 Buy
Biosynth Carbosynth FI143182 Ivacaftor 10mg $95 2021-12-16 Buy
Biosynth Carbosynth FI143182 Ivacaftor 50mg $332.5 2021-12-16 Buy
Cayman Chemical 15145 Ivacaftor ≥98% 1mg $33 2024-03-01 Buy
Cayman Chemical 15145 Ivacaftor ≥98% 5mg $131 2024-03-01 Buy
Cayman Chemical 15145 Ivacaftor ≥98% 10mg $245 2024-03-01 Buy

Properties

Melting point :212-215°C
Boiling point :550.4±50.0 °C(Predicted)
Density :1.187
storage temp. :Refrigerator
solubility :DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka :11.08±0.23(Predicted)
form :Solid
color :White to Light Brown
InChI :InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
InChIKey :PURKAOJPTOLRMP-UHFFFAOYSA-N
SMILES :N1C2=C(C=CC=C2)C(=O)C(C(NC2=CC(O)=C(C(C)(C)C)C=C2C(C)(C)C)=O)=C1

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). A glycine-to-aspartic acid missense mutation at codon 551 (G551D) is a common mutation associated with a severe CF phenotype. Ivacaftor is an orally bioavailable CFTR potentiator that improves chloride transport. It increases the forskolin-induced CFTR-mediated epithelial current in cells expressing the G551D mutation by ~4-fold (EC50 = 100 nM) but has no effect on current in the absence of forskolin. Ivacaftor increases chloride secretion in cultured human CF bronchial epithelial cells carrying the G551D mutation on one allele and the common delta F508 processing mutation on the other allele. It binds CFTR directly and causes CFTR channel opening by an ATP-independent mechanism. It effectively improves sweat chloride in vivo while improving lung function when at least one G551D CFTR mutation is present.

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