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ChemicalBook >> CAS DataBase List >> Quizartinib

Quizartinib

Quizartinib  price.
  • $28 - $5280
  • Product name: Quizartinib
  • CAS: 950769-58-1
  • MF: C29H32N6O4S
  • MW: 560.67
  • EINECS:
  • MDL Number:MFCD18074524
  • Synonyms:N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea AC-220;quizartinib (FLT3 inhibitor);1-(5-(tert-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)-benzo[d]imidazo[2,1-b]thiazol-2-y;Quizartinib AC-220;2-(4-AMinophenyl)-7-(2-Morpholin-4-yl-ethoxy)iMidazo[2,1-b]-[1,3]benzothiazole;N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-Morpholin-4-ylethoxy)iMidazo[2,1-b][1,3]benzothiazol-2-yl];AC220 (Quizartinib);AC220 (Quizartinib, AC010220)
42 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Tocris
  • TRC
  • Usbiological
Package
  • 20mg
  • 25mg
  • 50mg
  • 10
  • 100mg
  • 200mg
  • 500μg
  • 1MG
  • 1unit
  • 5MG
  • 10MG
  • 50
  • 10mM(in 1mL DMSO)
  • 250mg
  • 500mg
  • 1g
  • 2g
  • 5g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1003-M100
  • Product descriptionQuizartinib ≥95%
  • Packaging100mg
  • Price$1458
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberV2458
  • Product descriptionQuizartinib
  • Packaging100mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000393
  • Product descriptionQUIZARTINIB 95.00%
  • Packaging1MG
  • Price$705.57
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000393
  • Product descriptionQUIZARTINIB 95.00%
  • Packaging5MG
  • Price$826.07
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000393
  • Product descriptionQUIZARTINIB 95.00%
  • Packaging10MG
  • Price$890.39
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5793
  • Product descriptionQuizartinib(AC220)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5793
  • Product descriptionQuizartinib(AC220)
  • Packaging5mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5793
  • Product descriptionQuizartinib(AC220)
  • Packaging10mM(in 1mL DMSO)
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5793
  • Product descriptionQuizartinib(AC220)
  • Packaging25mg
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5793
  • Product descriptionQuizartinib(AC220)
  • Packaging100mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60241
  • Product descriptionQuizartinib(AC220) ≥98%
  • Packaging20mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154726
  • Product descriptionQuizartinib (AC220) >98%
  • Packaging100mg
  • Price$542.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154726
  • Product descriptionQuizartinib (AC220) >98%
  • Packaging250mg
  • Price$986
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154726
  • Product descriptionQuizartinib (AC220) >98%
  • Packaging1g
  • Price$2023
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFQ32834
  • Product descriptionQuizartinib
  • Packaging10mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFQ32834
  • Product descriptionQuizartinib
  • Packaging25mg
  • Price$75
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1003-M100 Quizartinib ≥95% 100mg $1458 2021-12-16 Buy
AK Scientific V2458 Quizartinib 100mg $240 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000393 QUIZARTINIB 95.00% 1MG $705.57 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000393 QUIZARTINIB 95.00% 5MG $826.07 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000393 QUIZARTINIB 95.00% 10MG $890.39 2021-12-16 Buy
ApexBio Technology A5793 Quizartinib(AC220) 1unit $28 2021-12-16 Buy
ApexBio Technology A5793 Quizartinib(AC220) 5mg $55 2021-12-16 Buy
ApexBio Technology A5793 Quizartinib(AC220) 10mM(in 1mL DMSO) $70 2021-12-16 Buy
ApexBio Technology A5793 Quizartinib(AC220) 25mg $165 2021-12-16 Buy
ApexBio Technology A5793 Quizartinib(AC220) 100mg $420 2021-12-16 Buy
Arctom CFN60241 Quizartinib(AC220) ≥98% 20mg $238 2021-12-16 Buy
Biorbyt Ltd orb154726 Quizartinib (AC220) >98% 100mg $542.3 2021-12-16 Buy
Biorbyt Ltd orb154726 Quizartinib (AC220) >98% 250mg $986 2021-12-16 Buy
Biorbyt Ltd orb154726 Quizartinib (AC220) >98% 1g $2023 2021-12-16 Buy
Biosynth Carbosynth FQ32834 Quizartinib 10mg $40 2021-12-16 Buy
Biosynth Carbosynth FQ32834 Quizartinib 25mg $75 2021-12-16 Buy

Properties

Density :1.39±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :White powder.
pka :12.59±0.70(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

Description

Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3; Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of 0.56 nM. At 1 mg/kg/day, quizartinib has been shown to extend survival in a mouse model of FLT3-ITD acute myeloid leukemia and to eradicate tumors in an FLT3-dependent mouse xenograft model at 10 mg/kg.

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