Brigatinib
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- $5 - $1504.5
- Product name: Brigatinib
- CAS: 1197953-54-0
- MF: C29H39ClN7O2P
- MW: 584.09
- EINECS:1592732-453-0
- MDL Number:
- Synonyms:Brigatinib;Brigatinib, AP26113;5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine;atinib;Bri atinib ;2,4-Pyrimidinediamine, 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-;Brigatinib USP/EP/BP;1197953-54-0 Brigatinib
34 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 5g
- ManufacturerAdipogen Life Sciences
- Product numberCDX-B0374-M005
- Product descriptionBrigatinib ≥98%(HPLC)
- Packaging5mg
- Price$71
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number9856BB
- Product descriptionBrigatinib
- Packaging50mg
- Price$171
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number9856BB
- Product descriptionBrigatinib
- Packaging100mg
- Price$239
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number9856BB
- Product descriptionBrigatinib
- Packaging500mg
- Price$522
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151843
- Product description(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+%
- Packaging50mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151843
- Product description(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+%
- Packaging100mg
- Price$8
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151843
- Product description(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+%
- Packaging250mg
- Price$13
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151843
- Product description(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+%
- Packaging1g
- Price$32
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151843
- Product description(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+%
- Packaging5g
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0028650
- Product descriptionBRIGATINIB 95.00%
- Packaging5MG
- Price$499.63
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2978
- Product descriptionBrigatinib-AP26113|Alunbrig 99%
- Packaging50mg
- Price$264
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611591
- Product descriptionBrigatinib
- Packaging100mg
- Price$414.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb154746
- Product descriptionBrigatinib(AP26113) >98%
- Packaging100mg
- Price$510
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611591
- Product descriptionBrigatinib
- Packaging250mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb154746
- Product descriptionBrigatinib(AP26113) >98%
- Packaging250mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611591
- Product descriptionBrigatinib
- Packaging1g
- Price$1208.7
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | CDX-B0374-M005 | Brigatinib ≥98%(HPLC) | 5mg | $71 | 2021-12-16 | Buy |
| AK Scientific | 9856BB | Brigatinib | 50mg | $171 | 2021-12-16 | Buy |
| AK Scientific | 9856BB | Brigatinib | 100mg | $239 | 2021-12-16 | Buy |
| AK Scientific | 9856BB | Brigatinib | 500mg | $522 | 2021-12-16 | Buy |
| Ambeed | A151843 | (2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+% | 50mg | $5 | 2021-12-16 | Buy |
| Ambeed | A151843 | (2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+% | 100mg | $8 | 2021-12-16 | Buy |
| Ambeed | A151843 | (2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+% | 250mg | $13 | 2021-12-16 | Buy |
| Ambeed | A151843 | (2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+% | 1g | $32 | 2021-12-16 | Buy |
| Ambeed | A151843 | (2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+% | 5g | $110 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0028650 | BRIGATINIB 95.00% | 5MG | $499.63 | 2021-12-16 | Buy |
| Axon Medchem | Axon2978 | Brigatinib-AP26113|Alunbrig 99% | 50mg | $264 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611591 | Brigatinib | 100mg | $414.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb154746 | Brigatinib(AP26113) >98% | 100mg | $510 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611591 | Brigatinib | 250mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb154746 | Brigatinib(AP26113) >98% | 250mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611591 | Brigatinib | 1g | $1208.7 | 2021-12-16 | Buy |
Properties
Melting point :>203°C (dec.)
Boiling point :781.8±70.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (1 mg/ml with warming)
form :solid
pka :8.14±0.42(Predicted)
color :White to off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :AILRADAXUVEEIR-UHFFFAOYSA-N
SMILES :C1(NC2=CC=C(N3CCC(N4CCN(C)CC4)CC3)C=C2OC)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1
CAS DataBase Reference :1197953-54-0
Boiling point :781.8±70.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (1 mg/ml with warming)
form :solid
pka :8.14±0.42(Predicted)
color :White to off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :AILRADAXUVEEIR-UHFFFAOYSA-N
SMILES :C1(NC2=CC=C(N3CCC(N4CCN(C)CC4)CC3)C=C2OC)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1
CAS DataBase Reference :1197953-54-0
Safety Information
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Description
Brigatinib is a small molecule inhibitor of both ALK and EGFR [195]. In preclinical models, “triple-mutant EGFR”-positive cells (activating EGFR mutation/ T790M/C797S) responded to the combination of brigatinib with an anti-EGFR monoclonal antibody, cetuximab or panitumumab [196]. Single-agent activity of brigatinib in a phase I/II trial was only 5% [197], possibly compounded by low plasma concentrations [196], but the addition of an anti-EGFR monoclonal antibody remains to be clinically tested. The preclinical data with brigatinib and EAI045?in laboratory models with a C797S mutation demonstrate that combination therapies with an anti-EGFR monoclonal antibody may lead to overcoming resistance to osimertinib.More related product prices
PF-06463922 Crizotinib AP26113 BKM120 (NVP-BKM120, Buparlisib) Ceritinib (LDK378) INCB28060 Olaparib Afatinib (BIBW 2992) Dacomitinib (PF299804) BIBW2992 DiMaleate Enzalutamide (MDV3100) 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Pazopanib Everolimus AZD-9291Related product price
- PF-06463922
$37-1335 - Crizotinib
$5-1963.5 - AP26113
$28-1169
Suppliers and manufacturers
AFINE CHEMICALS LIMITED
Jinan Good Medical Technology Co.,Ltd
Capot Chemical Co.,Ltd.
