Afatinib dimaleate
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- $41 - $1841
- Product name: Afatinib dimaleate
- CAS: 850140-73-7
- MF: C28H29ClFN5O7
- MW: 602.02
- EINECS:810-416-1
- MDL Number:MFCD28969755
- Synonyms:BIBW2992 DiMaleate;BIBW2992-MA2;Afatinib (diMaleate), BIBW2992;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-, (2Z)-2-butenedioate (1:2);(2E)-N-(4-[(3-chloro-4-fluorophenyl)aMino]-7-{[(3S);Afatinib double Maleate;Afatinib (BIBW2992) Dimaleate;N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-(2E)-2-butenamide,(2Z)-2-butenedioate (1:2)
28 prices
Selected condition：
Brand
- A1 Biochem Labs
- AK Scientific
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
Package
- 5mg
- 50mg
- 10mg
- 10
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 50
- 10mM(in 1mL DMSO)
- 5G
- ManufacturerA1 Biochem Labs
- Product number6566399
- Product descriptionAfatinib(dimaleate) 98%
- Packaging5G
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3423AH
- Product descriptionAfatinibDimaleate
- Packaging250mg
- Price$159
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3145
- Product descriptionAfatinibdimaleate
- Packaging5mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3145
- Product descriptionAfatinibdimaleate
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3145
- Product descriptionAfatinibdimaleate
- Packaging10mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3145
- Product descriptionAfatinibdimaleate
- Packaging50mg
- Price$97
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146151
- Product descriptionBIBW2992-MA2 (Afatinib dimaleate) >98%
- Packaging100mg
- Price$414.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146151
- Product descriptionBIBW2992-MA2 (Afatinib dimaleate) >98%
- Packaging250mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146151
- Product descriptionBIBW2992-MA2 (Afatinib dimaleate) >98%
- Packaging1g
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBA162012
- Product descriptionAfatinib dimaleate
- Packaging10mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBA162012
- Product descriptionAfatinib dimaleate
- Packaging50mg
- Price$262.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21567
- Product descriptionAfatinib (maleate) ≥95%
- Packaging250mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21567
- Product descriptionAfatinib (maleate) ≥95%
- Packaging500mg
- Price$176
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21567
- Product descriptionAfatinib (maleate) ≥95%
- Packaging1g
- Price$330
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21567
- Product descriptionAfatinib (maleate) ≥95%
- Packaging5g
- Price$1002
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM142622
- Product description(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamidedimaleate 98%
- Packaging250mg
- Price$186
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A1 Biochem Labs | 6566399 | Afatinib(dimaleate) 98% | 5G | $450 | 2021-12-16 | Buy |
| AK Scientific | 3423AH | AfatinibDimaleate | 250mg | $159 | 2021-12-16 | Buy |
| ApexBio Technology | A3145 | Afatinibdimaleate | 5mg | $41 | 2021-12-16 | Buy |
| ApexBio Technology | A3145 | Afatinibdimaleate | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A3145 | Afatinibdimaleate | 10mg | $68 | 2021-12-16 | Buy |
| ApexBio Technology | A3145 | Afatinibdimaleate | 50mg | $97 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146151 | BIBW2992-MA2 (Afatinib dimaleate) >98% | 100mg | $414.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146151 | BIBW2992-MA2 (Afatinib dimaleate) >98% | 250mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146151 | BIBW2992-MA2 (Afatinib dimaleate) >98% | 1g | $1208.7 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BA162012 | Afatinib dimaleate | 10mg | $75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BA162012 | Afatinib dimaleate | 50mg | $262.5 | 2021-12-16 | Buy |
| Cayman Chemical | 21567 | Afatinib (maleate) ≥95% | 250mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 21567 | Afatinib (maleate) ≥95% | 500mg | $176 | 2024-03-01 | Buy |
| Cayman Chemical | 21567 | Afatinib (maleate) ≥95% | 1g | $330 | 2024-03-01 | Buy |
| Cayman Chemical | 21567 | Afatinib (maleate) ≥95% | 5g | $1002 | 2024-03-01 | Buy |
| Chemenu | CM142622 | (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamidedimaleate 98% | 250mg | $186 | 2021-12-16 | Buy |
Properties
Melting point :>237oC (dec.)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Pale Yellow
InChIKey :LIENDGDDWJRJLO-LBXKZPGENA-N
SMILES :C(/C(=O)O)=C/C(=O)O.N(C1C=CC(F)=C(Cl)C=1)C1=NC=NC2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC1=2 |&1:25,r|
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Pale Yellow
InChIKey :LIENDGDDWJRJLO-LBXKZPGENA-N
SMILES :C(/C(=O)O)=C/C(=O)O.N(C1C=CC(F)=C(Cl)C=1)C1=NC=NC2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC1=2 |&1:25,r|
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
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Description
Afatinib dimaleate was approved by the U.S. Food and Drug Administration (FDA) in 2013 for the treatment of non-small cell lung cancer (NSCLC). Specifically, it was approved for patients presenting with metastatic NSCLC tumors which contain epidermal growth factor receptor (EGFR) exon deletions or exon 21 mutations. Afatinib dimaleate is a covalent inhibitor of ErbB tyrosine kinases (tyk), which downregulates ErbB signaling by irreversible binding of EGFR tyk binding sites. While no manufacturing route has been disclosed to date, the most scalable published route likely derives from two Boehringer Ingelheim patents.More related product prices
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- 162012-69-3 Afatinib (BIBW 2992) 86087-23-2 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Afatinib (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine trans-4-Dimethylaminocrotonic acid hydrochloride Olaparib Nintedanib Ethanesulfonate Salt 918504-65-1 PLERIXAFOR CrizotinibRelated product price
- 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
$12-1850 - 162012-69-3
$6-1252.83 - Afatinib (BIBW 2992)
$24-2658.8
Suppliers and manufacturers
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD
Shandong Risen-Sun Pharmaceutical Co., Ltd
Shanghai Famo Biotech Co Ltd
Guangzhou Tosun Pharmaceutical Ltd
Frapp's ChemicalNFTZ Co., Ltd.
