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ChemicalBook >> CAS DataBase List >> AP26113

AP26113

AP26113 price.
  • $28 - $1169
  • Product name: AP26113
  • CAS: 1197958-12-5
  • MF: C26H34ClN6O2P
  • MW: 529.01
  • EINECS:234-394-2
  • MDL Number:MFCD23704187
  • Synonyms:5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine;AP26113-ANALOG;(2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)ami;AP26113;AP26113/AP-26113;5-chloro-N2-(4-(4-(diMethylaMino)piperidin-1-yl)-2-Methoxy-5-Methylphenyl)-N4-(2-(diMethylphosphoryl)phenyl)pyriMidine-2,4-diaMine;5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinediamine;5-Chloro-N2-[4-[4-(diMethylaMino)-1-piperidinyl]-2-Methoxyphenyl]-N4-[2-(diMethylphosphinyl)phenyl]
29 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
  • Usbiological
Package
  • 1mg
  • 25mg
  • 100mg
  • 250mg
  • 1g
  • 1unit
  • 5MG
  • 10mg
  • 50mg
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product number2218AH
  • Product description(2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
  • Packaging10mg
  • Price$151
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2218AH
  • Product description(2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
  • Packaging50mg
  • Price$404
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0026216
  • Product descriptionAP-26113 95.00%
  • Packaging5MG
  • Price$499.71
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1367
  • Product descriptionAP26113
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1367
  • Product descriptionAP26113
  • Packaging5mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1367
  • Product descriptionAP26113
  • Packaging10mM(in 1mL DMSO)
  • Price$93
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1367
  • Product descriptionAP26113
  • Packaging10mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1367
  • Product descriptionAP26113
  • Packaging50mg
  • Price$333
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1367
  • Product descriptionAP26113
  • Packaging100mg
  • Price$428
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD76641
  • Product descriptionAP 26113
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD76641
  • Product descriptionAP 26113
  • Packaging50mg
  • Price$262.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18775
  • Product descriptionALK-IN-1 ≥98%
  • Packaging1mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18775
  • Product descriptionALK-IN-1 ≥98%
  • Packaging5mg
  • Price$201
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18775
  • Product descriptionALK-IN-1 ≥98%
  • Packaging10mg
  • Price$370
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18775
  • Product descriptionALK-IN-1 ≥98%
  • Packaging50mg
  • Price$1169
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM166858
  • Product description(2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98%
  • Packaging100mg
  • Price$252
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2218AH (2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 10mg $151 2021-12-16 Buy
AK Scientific 2218AH (2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 50mg $404 2021-12-16 Buy
American Custom Chemicals Corporation API0026216 AP-26113 95.00% 5MG $499.71 2021-12-16 Buy
ApexBio Technology A1367 AP26113 1unit $28 2021-12-16 Buy
ApexBio Technology A1367 AP26113 5mg $84 2021-12-16 Buy
ApexBio Technology A1367 AP26113 10mM(in 1mL DMSO) $93 2021-12-16 Buy
ApexBio Technology A1367 AP26113 10mg $147 2021-12-16 Buy
ApexBio Technology A1367 AP26113 50mg $333 2021-12-16 Buy
ApexBio Technology A1367 AP26113 100mg $428 2021-12-16 Buy
Biosynth Carbosynth FD76641 AP 26113 10mg $75 2021-12-16 Buy
Biosynth Carbosynth FD76641 AP 26113 50mg $262.5 2021-12-16 Buy
Cayman Chemical 18775 ALK-IN-1 ≥98% 1mg $68 2024-03-01 Buy
Cayman Chemical 18775 ALK-IN-1 ≥98% 5mg $201 2024-03-01 Buy
Cayman Chemical 18775 ALK-IN-1 ≥98% 10mg $370 2024-03-01 Buy
Cayman Chemical 18775 ALK-IN-1 ≥98% 50mg $1169 2024-03-01 Buy
Chemenu CM166858 (2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98% 100mg $252 2021-12-16 Buy

Properties

Boiling point :737.6±70.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥26.45 mg/mL in DMSO; insoluble in H2O; ≥55.9 mg/mL in EtOH
form :solid
pka :9.27±0.20(Predicted)
color :White to off-white
CAS DataBase Reference :1197958-12-5

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively). It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.

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