Capmatinib
|
- $50 - $1208.7
- Product name: Capmatinib
- CAS: 1029712-80-8
- MF: C23H17FN6O
- MW: 412.42
- EINECS:813-241-9
- MDL Number:MFCD18633285
- Synonyms:INCB028060;CapMatinib (INCB28060);CapMatinib;NC280 BenzaMide,2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-;NVP-INC280;2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Capmatinib (INCB28060);INCB28060, INC280;BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]- INCB28060
28 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
Package
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 1000mg
- 10g
- ManufacturerAK Scientific
- Product numberY0337
- Product description2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide
- Packaging10mg
- Price$153
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0337
- Product description2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide
- Packaging50mg
- Price$205
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0337
- Product description2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide
- Packaging100mg
- Price$259
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013709
- Product description2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YLMETHYL)IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE 95.00%
- Packaging10MG
- Price$315
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8448
- Product descriptionINCB28060
- Packaging10mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8448
- Product descriptionINCB28060
- Packaging50mg
- Price$315
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8448
- Product descriptionINCB28060
- Packaging100mg
- Price$525
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60251
- Product descriptionCapmatinib(INCB28060) ≥98%
- Packaging20mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181031
- Product descriptionCapmatinib(INCB28060) >98%
- Packaging100mg
- Price$414.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181031
- Product descriptionCapmatinib(INCB28060) >98%
- Packaging250mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181031
- Product descriptionCapmatinib(INCB28060) >98%
- Packaging1000mg
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFF40658
- Product descriptionCapmatinib
- Packaging250mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFF40658
- Product descriptionCapmatinib
- Packaging500mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number20056
- Product descriptionINCB 28060 ≥98%
- Packaging5mg
- Price$88
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20056
- Product descriptionINCB 28060 ≥98%
- Packaging10mg
- Price$157
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20056
- Product descriptionINCB 28060 ≥98%
- Packaging50mg
- Price$647
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y0337 | 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide | 10mg | $153 | 2021-12-16 | Buy |
| AK Scientific | Y0337 | 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide | 50mg | $205 | 2021-12-16 | Buy |
| AK Scientific | Y0337 | 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide | 100mg | $259 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013709 | 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YLMETHYL)IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE 95.00% | 10MG | $315 | 2021-12-16 | Buy |
| ApexBio Technology | A8448 | INCB28060 | 10mg | $98 | 2021-12-16 | Buy |
| ApexBio Technology | A8448 | INCB28060 | 50mg | $315 | 2021-12-16 | Buy |
| ApexBio Technology | A8448 | INCB28060 | 100mg | $525 | 2021-12-16 | Buy |
| Arctom | CFN60251 | Capmatinib(INCB28060) ≥98% | 20mg | $50 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181031 | Capmatinib(INCB28060) >98% | 100mg | $414.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181031 | Capmatinib(INCB28060) >98% | 250mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181031 | Capmatinib(INCB28060) >98% | 1000mg | $1208.7 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FF40658 | Capmatinib | 250mg | $550 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FF40658 | Capmatinib | 500mg | $800 | 2021-12-16 | Buy |
| Cayman Chemical | 20056 | INCB 28060 ≥98% | 5mg | $88 | 2024-03-01 | Buy |
| Cayman Chemical | 20056 | INCB 28060 ≥98% | 10mg | $157 | 2024-03-01 | Buy |
| Cayman Chemical | 20056 | INCB 28060 ≥98% | 50mg | $647 | 2024-03-01 | Buy |
Properties
Melting point :>250°C (dec.)
Density :1.40
vapor pressure :0-0Pa at 20-25℃
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.82±0.46(Predicted)
form :Solid
color :Pale Yellow to Light Yellow
InChI :InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
InChIKey :LIOLIMKSCNQPLV-UHFFFAOYSA-N
SMILES :C(NC)(=O)C1=CC=C(C2=NN3C(CC4=CC=C5C(=C4)C=CC=N5)=CN=C3N=C2)C=C1F
LogP :1.6-2.2 at 35℃ and pH7-9
Density :1.40
vapor pressure :0-0Pa at 20-25℃
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.82±0.46(Predicted)
form :Solid
color :Pale Yellow to Light Yellow
InChI :InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
InChIKey :LIOLIMKSCNQPLV-UHFFFAOYSA-N
SMILES :C(NC)(=O)C1=CC=C(C2=NN3C(CC4=CC=C5C(=C4)C=CC=N5)=CN=C3N=C2)C=C1F
LogP :1.6-2.2 at 35℃ and pH7-9
Safety Information
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Description
INCB 28060 is an inhibitor of heptatocyte growth factor receptor (HGFR, also known as c-Met), potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM). It blocks cell proliferation and migration or induces apoptosis in different types of cancer cells. INCB 28060 is orally bioavailable and inhibits the growth of HGFR-dependent tumors in mice. It also improves efficacy of gemcitabine in a mouse pancreatic cancer model and reduces migration and adhesion in ovarian cancer cell models.Related product price
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