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ChemicalBook >> CAS DataBase List >> Topotecan hydrochloride

Topotecan hydrochloride

Topotecan hydrochloride price.
  • $5 - $1490
  • Product name: Topotecan hydrochloride
  • CAS: 119413-54-6
  • MF: C23H24ClN3O5
  • MW: 457.91
  • EINECS:601-607-9
  • MDL Number:MFCD00866235
  • Synonyms:1,4-di(4-benzhydryloxy-2-butynyl)piperazine;1,4-di(4-benzyloxy-2-butynyl)piperazine;(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-(H-Pyrano[3' , 4':6,7]indolizino[1,2-b]quinoline-3,14[4H,12H]-dione monohydrochloride;Topotecan Hydrochloride（TPT）;S-(6-thioxo-1,6-dihydro-pyrimidin-4-yl)-isothiourea;Topotecan hydrochloride(NSC-609699);Topotecan, Hydrochloride Salt;Toputecan hydrochloride
61 prices
Selected condition：
Brand
  • ACHEMBLOCK
  • AHH
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Chemtos
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 2.5mg
  • 5mg
  • 10mg
  • 20mg
  • 50
  • 0.025g
  • 25mg
  • 50mg
  • 10mM(in 1mL DMSO)
  • 100mg
  • 250mg
  • 500mg
  • 1G
  • 5G
  • 10g
  • ManufacturerACHEMBLOCK
  • Product numberO32532
  • Product description(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98%
  • Packaging1G
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32532
  • Product description(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98%
  • Packaging5G
  • Price$485
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberAPI-1294
  • Product descriptionTopotecanhydrochloride 98%
  • Packaging0.025g
  • Price$820
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH030
  • Product descriptionTopotecanHCl
  • Packaging25mg
  • Price$78
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH030
  • Product descriptionTopotecanHCl
  • Packaging50mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ20654
  • Product descriptionTopotecanHCl
  • Packaging5g
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ98672
  • Product descriptionTopotecanHCl
  • Packaging10g
  • Price$950
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA122669
  • Product description(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98%
  • Packaging10mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA122669
  • Product description(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98%
  • Packaging50mg
  • Price$13
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA122669
  • Product description(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98%
  • Packaging100mg
  • Price$21
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA122669
  • Product description(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98%
  • Packaging250mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA122669
  • Product description(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98%
  • Packaging1g
  • Price$107
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA122669
  • Product description(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98%
  • Packaging5g
  • Price$419
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA122669
  • Product description(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98%
  • Packaging10g
  • Price$732
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2296
  • Product descriptionTopotecanHCl
  • Packaging10mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2296
  • Product descriptionTopotecanHCl
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ACHEMBLOCK O32532 (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98% 1G $180 2021-12-16 Buy
ACHEMBLOCK O32532 (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98% 5G $485 2021-12-16 Buy
AHH API-1294 Topotecanhydrochloride 98% 0.025g $820 2021-12-16 Buy
AK Scientific H030 TopotecanHCl 25mg $78 2021-12-16 Buy
AK Scientific H030 TopotecanHCl 50mg $144 2021-12-16 Buy
AK Scientific J20654 TopotecanHCl 5g $720 2021-12-16 Buy
AK Scientific J98672 TopotecanHCl 10g $950 2021-12-16 Buy
Ambeed A122669 (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98% 10mg $5 2021-12-16 Buy
Ambeed A122669 (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98% 50mg $13 2021-12-16 Buy
Ambeed A122669 (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98% 100mg $21 2021-12-16 Buy
Ambeed A122669 (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98% 250mg $40 2021-12-16 Buy
Ambeed A122669 (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98% 1g $107 2021-12-16 Buy
Ambeed A122669 (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98% 5g $419 2021-12-16 Buy
Ambeed A122669 (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride 98% 10g $732 2021-12-16 Buy
ApexBio Technology B2296 TopotecanHCl 10mg $40 2021-12-16 Buy
ApexBio Technology B2296 TopotecanHCl 10mM(in 1mL DMSO) $55 2021-12-16 Buy

Properties

Melting point :213-218°C
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form :Light yellow to greenish powder.
color :White to Off-White
Stability :Hygroscopic
CAS DataBase Reference :119413-54-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Topotecan is a water soluble analog of the alkaloid camptothecin that potently inhibits DNA topoisomerase I. It induces cytoxicity and DNA damage in human HT-29 colon adenocarcinoma cells with IC50 values of 33 nM and 0.28 μM, respectively. Topotecan demonstrates a broad spectrum of antitumor activity against a variety of other tumors including ovarian cancer, cervical cancer, neuroblastoma, brainstem glioma, and Ewing’s sarcoma.

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