10-Hydroxycamptothecin
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- $16 - $1490
- Product name: 10-Hydroxycamptothecin
- CAS: 19685-09-7
- MF: C20H16N2O5
- MW: 364.35
- EINECS:805-668-4
- MDL Number:MFCD00189425
- Synonyms:Camptothecae Acuminatae extract;hydrate,(s)-dihydroxy ;hydroxy-camptotheci ;Hydroxycamptothencine;(20S)-10-HYDROXYCAMPTOTHECIN 98%;(20S)-10-Hydroxycamptothecin;HYDROCAMPTOTHECINE;CAMPTOTHECIN, 10-HYDROXY(SH)
46 prices
Selected condition：
Brand
- Abosyn
- AccelPharmtech
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AstaTech
- AvaChem
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- JR MediChem
- Labseeker
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10mg
- 20mg
- 50mg
- 500mg
- 10g
- 10
- 1g
- 5mg
- 25mg
- 5G
- 25g
- 100mg
- 250mg
- 10mM(in 1mL DMSO)
- ManufacturerAbosyn
- Product number61-3021
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95%-98%
- Packaging1g
- Price$306
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberFB2418
- Product description10-HydroxyCamptothecin 99%
- Packaging5G
- Price$310
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ11456
- Product description10-Hydroxycamptothecin
- Packaging25mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ11456
- Product description10-Hydroxycamptothecin
- Packaging100mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA155153
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging100mg
- Price$16
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA155153
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging1g
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA155153
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging250mg
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA155153
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging5g
- Price$56
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA155153
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging25g
- Price$557
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4745
- Product description(S)-10-Hydroxycamptothecin
- Packaging25mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4745
- Product description(S)-10-Hydroxycamptothecin
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4745
- Product description(S)-10-Hydroxycamptothecin
- Packaging100mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS020342
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98%
- Packaging100mg
- Price$16
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS020342
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98%
- Packaging250mg
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN99735
- Product description(S)-10-Hydroxycamptothecin ≥98%
- Packaging20mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS020342
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98%
- Packaging1g
- Price$55
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Abosyn | 61-3021 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95%-98% | 1g | $306 | 2021-12-16 | Buy |
| AccelPharmtech | FB2418 | 10-HydroxyCamptothecin 99% | 5G | $310 | 2021-12-16 | Buy |
| AK Scientific | J11456 | 10-Hydroxycamptothecin | 25mg | $39 | 2021-12-16 | Buy |
| AK Scientific | J11456 | 10-Hydroxycamptothecin | 100mg | $98 | 2021-12-16 | Buy |
| Ambeed | A155153 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 100mg | $16 | 2021-12-16 | Buy |
| Ambeed | A155153 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 1g | $30 | 2021-12-16 | Buy |
| Ambeed | A155153 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 250mg | $30 | 2021-12-16 | Buy |
| Ambeed | A155153 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 5g | $56 | 2021-12-16 | Buy |
| Ambeed | A155153 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 25g | $557 | 2021-12-16 | Buy |
| ApexBio Technology | B4745 | (S)-10-Hydroxycamptothecin | 25mg | $40 | 2021-12-16 | Buy |
| ApexBio Technology | B4745 | (S)-10-Hydroxycamptothecin | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| ApexBio Technology | B4745 | (S)-10-Hydroxycamptothecin | 100mg | $85 | 2021-12-16 | Buy |
| Arctom | AS020342 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98% | 100mg | $16 | 2021-12-16 | Buy |
| Arctom | AS020342 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98% | 250mg | $30 | 2021-12-16 | Buy |
| Arctom | CFN99735 | (S)-10-Hydroxycamptothecin ≥98% | 20mg | $40 | 2021-12-16 | Buy |
| Arctom | AS020342 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98% | 1g | $55 | 2021-12-16 | Buy |
Properties
Melting point :265-270°C
Boiling point :820.7±65.0 °C(Predicted)
Density :1.60
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form :powder to crystal
pka :8.93±0.40(Predicted)
color :White to Yellow to Orange
InChIKey :HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference :19685-09-7(CAS DataBase Reference)
Boiling point :820.7±65.0 °C(Predicted)
Density :1.60
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form :powder to crystal
pka :8.93±0.40(Predicted)
color :White to Yellow to Orange
InChIKey :HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference :19685-09-7(CAS DataBase Reference)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.More related product prices
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Suppliers and manufacturers
Capot Chemical Co.,Ltd.
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Biochempartner
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Hubei xin bonus chemical co. LTD
