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ChemicalBook >> CAS DataBase List >> Irinotecan hydrochloride trihydrate

Irinotecan hydrochloride trihydrate

Irinotecan hydrochloride trihydrate price.
  • $35 - $2016
  • Product name: Irinotecan hydrochloride trihydrate
  • CAS: 136572-09-3
  • MF: C33H45ClN4O9
  • MW: 677.18
  • EINECS:603-967-2
  • MDL Number:MFCD01765731
  • Synonyms:Irinotecan-d10 hydrochloride trihydrate;CPT-11 HCl Trihydrate;irinotecan hydrochloride hydrate;Irinotecanhydrochloridetrihydrate(CPT-11);IRINOTECON HCL TRIHYDRATE;[1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4',6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER, HCL TRIHYDRATE;(S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate ,99%;Irinotecan Hydrochloride (100 mg)
50 prices
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  • AHH
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Frontier Specialty Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
  • Usbiological
Package
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  • 250mg
  • 500mg
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  • 5G
  • 10g
  • ManufacturerAHH
  • Product numberAPI-1297
  • Product descriptionIrinotecan Hydrochloride Trihydrate 98%
  • Packaging0.25g
  • Price$890
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62370
  • Product descriptionIrinotecan hydrochloride trihydrate 99%
  • Packaging100mg
  • Price$172.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62370
  • Product descriptionIrinotecan hydrochloride trihydrate 99%
  • Packaging250mg
  • Price$337.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004969
  • Product descriptionIRINOTECAN HYDROCHLORIDE TRIHYDRATE 95.00%
  • Packaging25MG
  • Price$704.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004969
  • Product descriptionIRINOTECAN HYDROCHLORIDE TRIHYDRATE 95.00%
  • Packaging250MG
  • Price$1593.9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006883
  • Product descriptionIRINOTECAN-D10-HYDROCHLORIDE TRIHYDRATE 95.00%
  • Packaging5MG
  • Price$499.09
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2293
  • Product descriptionIrinotecanHClTrihydrate
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN60115
  • Product descriptionIrinotecanHCITrihydrate
  • Packaging20mg
  • Price$50
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number1023H
  • Product descriptionIrinotecan HCl Trihydrate
  • Packaging10mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1023H
  • Product descriptionIrinotecan HCl Trihydrate
  • Packaging100mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1023H
  • Product descriptionIrinotecan HCl Trihydrate
  • Packaging1g
  • Price$155
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1023H
  • Product descriptionIrinotecan HCl Trihydrate
  • Packaging10g
  • Price$890
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb61044
  • Product descriptionIrinotecan, Hydrochloride Salt, Trihydrate >99% pure
  • Packaging10g
  • Price$1929.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb61044
  • Product descriptionIrinotecan, Hydrochloride Salt, Trihydrate >99% pure
  • Packaging5G
  • Price$1111.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb61044
  • Product descriptionIrinotecan, Hydrochloride Salt, Trihydrate >99% pure
  • Packaging2g
  • Price$829.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb61044
  • Product descriptionIrinotecan, Hydrochloride Salt, Trihydrate >99% pure
  • Packaging1g
  • Price$668.1
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1297 Irinotecan Hydrochloride Trihydrate 98% 0.25g $890 2021-12-16 Buy
Alfa Aesar J62370 Irinotecan hydrochloride trihydrate 99% 100mg $172.65 2024-03-01 Buy
Alfa Aesar J62370 Irinotecan hydrochloride trihydrate 99% 250mg $337.65 2024-03-01 Buy
American Custom Chemicals Corporation INB0004969 IRINOTECAN HYDROCHLORIDE TRIHYDRATE 95.00% 25MG $704.55 2021-12-16 Buy
American Custom Chemicals Corporation INB0004969 IRINOTECAN HYDROCHLORIDE TRIHYDRATE 95.00% 250MG $1593.9 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006883 IRINOTECAN-D10-HYDROCHLORIDE TRIHYDRATE 95.00% 5MG $499.09 2021-12-16 Buy
ApexBio Technology B2293 IrinotecanHClTrihydrate 100mg $50 2021-12-16 Buy
Arctom CFN60115 IrinotecanHCITrihydrate 20mg $50 2021-12-16 Buy
AvaChem 1023H Irinotecan HCl Trihydrate 10mg $35 2021-12-16 Buy
AvaChem 1023H Irinotecan HCl Trihydrate 100mg $55 2021-12-16 Buy
AvaChem 1023H Irinotecan HCl Trihydrate 1g $155 2021-12-16 Buy
AvaChem 1023H Irinotecan HCl Trihydrate 10g $890 2021-12-16 Buy
Biorbyt Ltd orb61044 Irinotecan, Hydrochloride Salt, Trihydrate >99% pure 10g $1929.5 2021-12-16 Buy
Biorbyt Ltd orb61044 Irinotecan, Hydrochloride Salt, Trihydrate >99% pure 5G $1111.8 2021-12-16 Buy
Biorbyt Ltd orb61044 Irinotecan, Hydrochloride Salt, Trihydrate >99% pure 2g $829.6 2021-12-16 Buy
Biorbyt Ltd orb61044 Irinotecan, Hydrochloride Salt, Trihydrate >99% pure 1g $668.1 2021-12-16 Buy

Properties

Melting point :250-256°C (dec.)
Boiling point :257°C(lit.)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
form :White solid.
color :Yellow
Water Solubility :Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
Merck :14,5091
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference :136572-09-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P314 Get medical advice/attention if you feel unwell.
P330 Rinse mouth.
P403 Store in a well-ventilated place.

Description

Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3