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Postion:Product Catalog >API>Antineoplastic agents>Natural sources of antineoplastic>Topotecan hydrochloride
Topotecan hydrochloride
  • Topotecan hydrochloride
  • Topotecan hydrochloride
  • Topotecan hydrochloride
  • Topotecan hydrochloride
  • Topotecan hydrochloride

Topotecan hydrochloride NEW

Price Get Latest Price
Package 25KG
Min. Order: 1KG
Supply Ability: 50000KG/month
Update Time: 2023-08-29

Product Details

Product Name: Topotecan hydrochloride CAS No.: 119413-54-6
EC-No.: 601-607-9 Min. Order: 1KG
Purity: 99% Supply Ability: 50000KG/month
Release date: 2023/08/29

CAS:119413-54-6
MF:C23H24ClN3O5
MW:457.91
EINECS:601-607-9
Product Categories:Isotope Labelled Compounds;Active Pharmaceutical Ingredients;Isotope Labeled Compounds;Pharmaceuticals;Chiral Reagents;Inhibitors;straight chain compounds;Antineoplastic;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Anti-cancer & immunity;API;119413-54-6
Mol File:119413-54-6.mol
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Topotecan hydrochloride Chemical Properties
Melting point 213-218°C
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form Light yellow to greenish powder.
color White to Off-White
Stability:Hygroscopic
CAS DataBase Reference119413-54-6(CAS DataBase Reference)

Topotecan hydrochloride Usage And Synthesis
Anticancer drugTopotecan hydrochloride is a water-soluble derivative of camptothecin, which is the form of hydrochloride of topotecan. It is successfully developed by the SmithKline Beecham US company, and approved by the FDA in the United States in 1996. Its trade name is Hycamtin. It is applied in the treatment of ovarian cancer (OVC) as the second-line therapy.
In 1999 the US Food and Drug Administration (FDA) has approved topotecan hydrochloride as small cell lung cancer (SCLC) therapeutic drug. It has been available in the UK, Germany, France and other dozens of countries and regions. The Ⅲ clinical trials are ongoing for this medicine which is used to treat non-small cell lung cancer, cervical cancer, myelodysplastic syndrome.
Topotecan hydrochloride can enter the blood brain barrier. It has the same effect of oral and intravenous injection. The drug has low toxicity predictable bone marrow suppression, and other minor non-hematologic toxicity. Currently there are manufacturers, for clinical treatment of small cell lung cancer, ovarian cancer and other tumors.
Topotecan hydrochloride inhibits the activity of topoisomerase I, which is required for DNA replication. After intravenous injection, the product is hydrolyzed in the blood, and excreted by urinary. This product has a rapid serum clearance rate, which is 62L/h. It is widely distributed in vivo, and Its half-lifetime is about 2~3h. Preclinical trials have shown that the product has anti-tumor activity on all kinds of types of tumor. In I clinical trial, to patients with ovarian cancer that is cisplatin tolerance, this product also has significant anti-tumor effect.
Clinical studiesIn a open randomized trial, 226 cases who used cisplatin or carboplatin invalid or recurrent advanced ovarian cancer women changed to this product, and compared with paclitaxel. In 112 patients who used topotecan hydrochloride, 22 cases were effective, so the effective rate was 20%. In 114 patients treated with paclitaxel, 14 cases were effective, so the effective rate was 12%. Used this product for treatment which has made significant improvement in the average time of 23 weeks, while 14 weeks for paclitaxel. In a non-controlled trial to 111 women patients with refractory advanced ovarian cancer, 16 cases were preferabe after treatment, occupied with 14%, and the curative effect average time was 16-week, and the average survival time was 52-week. In an open trial, 67 cases were ineffective treated with cisplatin and paclitaxel for advanced ovarian cancer. However, 9 cases who changed to this product were effective, and the effective rate was 13%.
The above information is edited by the chemicalbook of Kui Ming.
Side effectsIt can appear toxicity of bone marrow suppression in limited doses, especially it can cause neutropenia. It often induced thrombocytopenia and anemia. Sometimes red blood cell and platelet transfusion is necessary. It can also be nausea, vomiting, hair loss, diarrhea, abdominal pain, gastritis and weakness, but all of them were mild.
UsesIt is used as antineoplastic agent.
DescriptionTopotecan is a chemotherapeutic agent medication and acts as a topoisomerase inhibitor. Topotecan is asynthetic, water-soluble analog of camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer and other cancer types.
Chemical PropertiesWhite Crystalline Solid
OriginatorHycamtin,SmithKline Beecham Pharmaceuticals,UK
UsesNaturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer)
Usesantineoplastic; topoisomerase I inhibitor
UsesA DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.

Packing &shipping&Payment

Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Quantity(Kilograms)1 - 10000>10000
Est. Time(days)5To be negotiated

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Article illustrationCompany information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.

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  • Since: 2017-12-08
  • Address: Building A, Enjoy city, Zhongshan East Road, Shijiazhuang city, Hebei province
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