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845959-50-4

中文名稱 米托蒽醌甲磺酸鹽
英文名稱 Mitoquinone mesylate
CAS 845959-50-4
分子式 C38H47O7PS
分子量 678.814
MOL 文件 845959-50-4.mol
更新日期 2024/12/13 09:49:02
845959-50-4 結(jié)構(gòu)式 845959-50-4 結(jié)構(gòu)式

基本信息

中文別名
米托蒽醌甲磺酸鹽
英文別名
MitoQ
MitoQ mesylate
MitoQ10 mesylate
Mitoquinol Mesylate
Mitoquinone mesylate
Mitoquinone mesylate, ethanol solution
Mitoquinone mesylate (Mitoquinone methanesulfonate
10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium,methanesulfonate

物理化學(xué)性質(zhì)

儲存條件-20°C
溶解度溶于二甲基亞砜。
形態(tài)蠟狀固體
顏色橙色
穩(wěn)定性可在-20°C下的DMSO中的溶液儲存長達3個月。

常見問題列表

生物活性
Mitoquinone mesylate (MitoQ mesylate, MitoQ10, Mitoubiquinone) 是一種基于TPP的線粒體mitochondria靶向抗氧化劑,可阻斷H2O2誘導(dǎo)的細胞內(nèi) ROS 反應(yīng)并防止氧化損傷。
靶點
TargetValue
mitochondria
()
ROS
()
體外研究

Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant.The optimal doses for Mitoquinone (MitoQ) and DecylTPP treatment are selected from dose-response experiments during 4-h cold storage (CS). The potential protective benefits of Mitoquinone treatment against CS injury are tested initially using MitoSOX Red, a mitochondrial-targeted fluorescent dye that measures mitochondrial superoxide generation. Normal rat kidney (NRK) cells exposed to CS result in a ~2-fold increase in fluorescence due to mitochondrial superoxide compared with untreated cells. Mitoquinone offers significant protection against CS-induced mitochondrial superoxide generation; whereas the control compound DecylTPP does not offer any protection. Mitoquinone treatment markedly decreases mitochondrial superoxide generation, whereas kidneys treated with DecylTPP have comparable levels of mitochondrial superoxide to kidneys exposed to CS alone.

體內(nèi)研究

Mitoquinone (MitoQ) treatment significantly reduces pancreatic oedema and neutrophil infiltration. MitoQ dose-dependently increases serum amylase with an approximate doubling at the higher dose. MitoQ treatment nearly doubles lung MPO activity induced by Caerulein with a significant increase of serum IL-6 levels also evident at 10?mg/kg (dose 1).

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