134-63-4
中文名稱
鹽酸洛貝林
英文名稱
alpha-Lobeline hydrochloride
CAS
134-63-4
EINECS 編號(hào)
205-150-2
分子式
C22H28ClNO2
MDL 編號(hào)
MFCD00082455
分子量
373.92
MOL 文件
134-63-4.mol
更新日期
2025/01/08 09:19:51
134-63-4 結(jié)構(gòu)式
基本信息
中文別名
2-[1-甲基-6-(beta-羥基苯乙基)-2-哌啶基]苯乙酮鹽酸鹽鹽酸洛貝林
洛貝林[山梗菜堿]鹽酸鹽
鹽酸山梗堿
洛貝啉
英文別名
2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenyl-ethyl]-1-methyl-2-piperidyl]-1-phenyl-ethanone hydrochloride[2-[(2R,6S)-6-[(2S)-2-HYDROXYPHENETHYL]]-1-METHYL-2-PIPERIDYL]ACETOPHENONE HYDROCHLORIDE
2-[6-(2-HYDROXY-2-PHENETHYL)-1-METHYL-2-PIPERIDYL]ACETOPHENONE HCL
2-(6-[2-HYDROXY-2-PHENYLETHYL]-1-METHYL-2-PIPERIDINYL)-1-PHENYLETHANONE HYDROCHLORIDE
A-LOBELINE HCL
A-LOBELINE, HYDROCHLORIDE
ALPHA-LOBELINE HYDROCHLORIDE
ALPHA-LOBELIN HCL
L-LOBELINE HYDROCHLORIDE
(-)-LOBELINE HCL
LOBELINE HCL, A-
(-)-LOBELINE HYDROCHLORIDE
LOBELINE HYDROCHLORIDE
(-)-id
2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-acetophenonhydrochlor
2-[6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl]-,hydrochloride,(-)-Acetophenone
Lobelinhydrochloride
2-(6-(2-hydroxy-2-phenethyl)-1-methyl-2-piperidyl)acetophenone hydrochloride
Apolipoprotein B (LDL), Sheep anti-Human, Guinea pig, Swine (NO X w/Bovine, Horse, Dog, Cat, Rabbit, Chicken, Goat, Mouse, Rat)
2-(6-[2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl)-1-phenylethanone, L-Lobeline, Hydrochloride
所屬類別
原料藥：中樞興奮藥物理化學(xué)性質(zhì)
熔點(diǎn)183-185 °C (dec.)(lit.)
比旋光度D20 -43° (c = 2)
折射率-57.5 ° (C=1, H2O)
儲(chǔ)存條件Inert atmosphere,Room Temperature
溶解度H2O: 25 mg/mL
形態(tài)powder
顏色white to off-white
旋光性 (optical activity)[α]20/D 56.8°, c = 2 in H2O
Merck5551
BRN3920196
LogP3.610 (est)
CAS 數(shù)據(jù)庫134-63-4(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301+H331
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼R23/25
安全說明S36/37/39-S45
危險(xiǎn)品運(yùn)輸編號(hào)UN 1544 6.1/PG 3
WGK Germany3
RTECS號(hào)OJ8490100
F8
危險(xiǎn)等級(jí)6.1(b)
包裝類別III
常見問題列表
用途
鹽酸洛貝林為反射性呼吸中樞興奮藥。由于刺激頸動(dòng)脈體及主動(dòng)脈弓化學(xué)感受器，反射性地興奮延髓呼吸中樞，對(duì)迷走神經(jīng)中樞和血管運(yùn)動(dòng)中樞也同時(shí)有反射性的興奮作用；對(duì)植物神經(jīng)節(jié)先興奮而后阻斷。用于各種原因引起的呼吸抑制。常用于新生兒窒息，一氧化碳、阿片中毒等。生物活性
Lobeline hydrochloride 是煙堿樣受體激動(dòng)劑, 作為有效的神經(jīng)元煙堿受體α3β2和α4β2拮抗劑。