Sodium cholate synthesis
- Product Name:Sodium cholate
- CAS Number:361-09-1
- Molecular formula:C24H41NaO5
- Molecular Weight:432.58
81-25-4
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$5.00/100mg
361-09-1
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$28.60/1MG
Yield:-
Reaction Conditions:
with sodium hydroxide in ethanol;water at 20; for 1 h;
Steps:
5.2. General procedure for the synthesis of 24-hydroxy-24,24-bisphosphonobile acid disodium salts 3b-5b and bile acids disodium salts 6b-8b
General procedure: 4 mmol of the bisphosphonobile acids 3a-5a, dissolved in 20 mL of EtOH/H2O (1:1 v/v), were treated with an aqueous solution of NaOH (8 mmol). The mixture was stirred for 1 h at r.t. The reaction mixture was lyophilized giving the expected disodium salts in almost quantitative yield.
References:
Bortolini, Olga;Fantin, Giancarlo;Fogagnolo, Marco;Rossetti, Stefano;Maiuolo, Loredana;Di Pompo, Gemma;Avnet, Sofia;Granchi, Donatella [European Journal of Medicinal Chemistry,2012,vol. 52,p. 221 - 229] Location in patent:experimental part