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ChemicalBook CAS DataBase List Diclofenac sodium
15307-79-6

Diclofenac sodium synthesis

13synthesis methods
Synthesis: Acylation of N-phenyl-2,6- dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide, which is fused with aluminum chloride to give 1-(2,6- dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly.
synthesis of Diclofenac sodium
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Yield:15307-79-6 96.1%

Reaction Conditions:

with sodium hydroxide in water;N,N-dimethyl-formamide at 80; for 24 h;

Steps:

1.2; 2.2; 3.2 (2) Synthesis of diclofenac sodium

25 g (0.08 mol) of Compound C, 160 mL of N,N-dimethylformamide were added to a three-necked flask, and the mixture was stirred and heated to 80 °C. After adding 8g (0.2mol) of NaOH and 35g of water to form a solution, continue the reaction for 24h, After completion of the reaction, the solvent was distilled off under reduced pressure, the residue was dissolved by heating with 200mL of water, decolorized with charcoal, suction filtered, the filtrate was cooled in an ice-water bath crystallization, filtration, The white crystalline powder diclofenac sodium was dried to 24.6 g, the yield was 96.1%, and the content determined by HPLC was 98.2%. The overall yield of the above reaction was 90.5%.

References:

CN109553544,2019,A Location in patent:Paragraph 0017-0026

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