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ChemicalBook >> CAS DataBase List >> UNC 0224

UNC 0224

UNC 0224 price.
  • $48 - $1800
  • Product name: UNC 0224
  • CAS: 1197196-48-7
  • MF: C26H43N7O2
  • MW: 485.67
  • EINECS:
  • MDL Number:MFCD18251564
  • Synonyms:UNC 0224;4-QuinazolinaMine, 7-[3-(diMethylaMino)propoxy]-2-(hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6-Methoxy-N-(1-Methyl-4-piperidinyl)-;N-Debenzyl-N-Methyl-O-deMethyl-O-(3-diMethylaMinopropyl)-BIX 01294;CS-1635;UNC-0224; UNC0224; UNC 0224;7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine;7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine;K373,G9a,UNC0224,PKMT,lysine,UNC 0224,SAR,stabilized,p53,inhibit,quinazoline,H3K9,UNC-0224,GLP,Inhibitor,Histone Methyltransferase,chromatin
22 prices
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Brand
  • AK Scientific
  • ApexBio Technology
  • Apolloscientific
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 10
  • 1mg
  • 50
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number4141AH
  • Product description7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
  • Packaging10mg
  • Price$253
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4503
  • Product descriptionUNC0224
  • Packaging10mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4503
  • Product descriptionUNC0224
  • Packaging50mg
  • Price$618
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0023
  • Product descriptionUNC0224
  • Packaging5mg
  • Price$149
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0023
  • Product descriptionUNC0224
  • Packaging10mg
  • Price$223
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0023
  • Product descriptionUNC0224
  • Packaging25mg
  • Price$507
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1789
  • Product descriptionUNC0224 99%
  • Packaging5mg
  • Price$93.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13631
  • Product descriptionUNC0224 ≥98%
  • Packaging1mg
  • Price$48
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13631
  • Product descriptionUNC0224 ≥98%
  • Packaging5mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13631
  • Product descriptionUNC0224 ≥98%
  • Packaging10mg
  • Price$210
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13631
  • Product descriptionUNC0224 ≥98%
  • Packaging50mg
  • Price$936
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2210
  • Product descriptionUNC0224 99.31%
  • Packaging5mg
  • Price$116
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2210
  • Product descriptionUNC0224 99.31%
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2210
  • Product descriptionUNC0224 99.31%
  • Packaging50mg
  • Price$840
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004330
  • Product descriptionUNC0224 98+%
  • Packaging25mg
  • Price$351
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004330
  • Product descriptionUNC0224 98+%
  • Packaging50mg
  • Price$665
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 4141AH 7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine 10mg $253 2021-12-16 Buy
ApexBio Technology A4503 UNC0224 10mg $147 2021-12-16 Buy
ApexBio Technology A4503 UNC0224 50mg $618 2021-12-16 Buy
Apolloscientific BISN0023 UNC0224 5mg $149 2021-12-16 Buy
Apolloscientific BISN0023 UNC0224 10mg $223 2021-12-16 Buy
Apolloscientific BISN0023 UNC0224 25mg $507 2021-12-16 Buy
Axon Medchem Axon1789 UNC0224 99% 5mg $93.5 2021-12-16 Buy
Cayman Chemical 13631 UNC0224 ≥98% 1mg $48 2024-03-01 Buy
Cayman Chemical 13631 UNC0224 ≥98% 5mg $117 2024-03-01 Buy
Cayman Chemical 13631 UNC0224 ≥98% 10mg $210 2024-03-01 Buy
Cayman Chemical 13631 UNC0224 ≥98% 50mg $936 2024-03-01 Buy
ChemScene CS-2210 UNC0224 99.31% 5mg $116 2021-12-16 Buy
ChemScene CS-2210 UNC0224 99.31% 10mg $180 2021-12-16 Buy
ChemScene CS-2210 UNC0224 99.31% 50mg $840 2021-12-16 Buy
Crysdot CD31004330 UNC0224 98+% 25mg $351 2021-12-16 Buy
Crysdot CD31004330 UNC0224 98+% 50mg $665 2021-12-16 Buy

Properties

Boiling point :641.0±65.0 °C(Predicted)
Density :1.141±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
form :Powder
pka :9.34±0.70(Predicted)
color :White to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM. Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase).

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