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ChemicalBook >> CAS DataBase List >> UNC2025

UNC2025

UNC2025 price.
  • $60 - $1700
  • Product name: UNC2025
  • CAS: 1429881-91-3
  • MF: C28H40N6O
  • MW: 476.66
  • EINECS:
  • MDL Number:MFCD28142874
  • Synonyms:(1r,4r)-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimi;UNC2025;(1R,4R)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol UNC-2025;mrx-6313;trans-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol;trans-4-[2-(Butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexanol;UNC2025 HCl;(1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol
24 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • DC Chemicals
  • TRC
  • Usbiological
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product number6686DW
  • Product description4-[2-(Butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB8016
  • Product descriptionUNC2025
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB8016
  • Product descriptionUNC2025
  • Packaging10mM(in 1mL DMSO)
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB8016
  • Product descriptionUNC2025
  • Packaging25mg
  • Price$315
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFU137733
  • Product descriptionUNC 2025
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFU137733
  • Product descriptionUNC 2025
  • Packaging50mg
  • Price$437.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16613
  • Product descriptionUNC2025 ≥98%
  • Packaging5mg
  • Price$75
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16613
  • Product descriptionUNC2025 ≥98%
  • Packaging10mg
  • Price$135
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16613
  • Product descriptionUNC2025 ≥98%
  • Packaging25mg
  • Price$319
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16613
  • Product descriptionUNC2025 ≥98%
  • Packaging50mg
  • Price$600
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM249397
  • Product descriptiontrans-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol 98%
  • Packaging100mg
  • Price$763
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3354
  • Product descriptionUNC2025 99.94%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3354
  • Product descriptionUNC2025 99.94%
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3354
  • Product descriptionUNC2025 99.94%
  • Packaging25mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3354
  • Product descriptionUNC2025 99.94%
  • Packaging50mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3354
  • Product descriptionUNC2025 99.94%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6686DW 4-[2-(Butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol 10mg $218 2021-12-16 Buy
ApexBio Technology B8016 UNC2025 5mg $105 2021-12-16 Buy
ApexBio Technology B8016 UNC2025 10mM(in 1mL DMSO) $105 2021-12-16 Buy
ApexBio Technology B8016 UNC2025 25mg $315 2021-12-16 Buy
Biosynth Carbosynth FU137733 UNC 2025 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FU137733 UNC 2025 50mg $437.5 2021-12-16 Buy
Cayman Chemical 16613 UNC2025 ≥98% 5mg $75 2024-03-01 Buy
Cayman Chemical 16613 UNC2025 ≥98% 10mg $135 2024-03-01 Buy
Cayman Chemical 16613 UNC2025 ≥98% 25mg $319 2024-03-01 Buy
Cayman Chemical 16613 UNC2025 ≥98% 50mg $600 2024-03-01 Buy
Chemenu CM249397 trans-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol 98% 100mg $763 2021-12-16 Buy
ChemScene CS-3354 UNC2025 99.94% 5mg $60 2021-12-16 Buy
ChemScene CS-3354 UNC2025 99.94% 10mg $100 2021-12-16 Buy
ChemScene CS-3354 UNC2025 99.94% 25mg $150 2021-12-16 Buy
ChemScene CS-3354 UNC2025 99.94% 50mg $250 2021-12-16 Buy
ChemScene CS-3354 UNC2025 99.94% 100mg $450 2021-12-16 Buy

Properties

Boiling point :677.5±65.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :≥23.85 mg/mL in DMSO; insoluble in EtOH; ≥6.09 mg/mL in H2O with ultrasonic
form :Powder
pka :14.63±0.40(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo. Pharmacokinetic studies suggest that orally administered UNC2025 at 3 mg/kg will suffice to provide 90% inhibition of Mer and Flt3 at 30 min.

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