Product Details
Product Name:
UNC0224 |
CAS No.:
1197196-48-7 |
Purity:
97.61% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | UNC0224 |
Description | UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM. |
In vitro | In G9a ECSD and CLOT assays, the IC50 values are 43 nM and 57 nM for UNC0224, respectively. In GLP ECSD and CLOT assays, the IC50 values are 50 nM and 58 nM for UNC0224, respectively. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3, and JMJD2E. In ITC experiments, the Kd of UNC0224 to the G9a protein is 23 nM[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 45 mg/mL (92.66 mM), Sonication is recommended.
|
Keywords | K373 | G9a | PKMT | lysine | UNC 0224 | SAR | stabilized | p53 | inhibit | quinazoline | UNC0224 | H3K9 | GLP | Inhibitor | Histone Methyltransferase | UNC-0224 | chromatin |
Inhibitors Related | BIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | GSK126 | MAK683 | EZM 2302 | EPZ015666 | AMI-1 free acid | MS37452 | MRTX-1719 |
Related Compound Libraries | Histone Modification Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |