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ChemicalBook >> CAS DataBase List >> UNC0646

UNC0646

UNC0646 price.
  • $48 - $3728.1
  • Product name: UNC0646
  • CAS: 1320288-17-2
  • MF: C36H59N7O2
  • MW: 621.9
  • EINECS:
  • MDL Number:MFCD22378486
  • Synonyms:UNC0646;N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine;UNC0646/UNC-0646;N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;(1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE;UNC 0646;UNC0646;UNC-0646;CS-792
32 prices
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Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 50
  • 1mg
  • 10
  • 10mg
  • 25mg
  • 2x25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number4143AH
  • Product descriptionN-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine
  • Packaging10mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number4143AH
  • Product descriptionN-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine
  • Packaging50mg
  • Price$612
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA880677
  • Product descriptionUNC0646 98+%
  • Packaging5mg
  • Price$66
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA880677
  • Product descriptionUNC0646 98+%
  • Packaging10mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA880677
  • Product descriptionUNC0646 98+%
  • Packaging25mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4504
  • Product descriptionUNC0646
  • Packaging10mg
  • Price$92
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1840
  • Product descriptionUNC0646 99%
  • Packaging2x25mg
  • Price$638
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146212
  • Product descriptionUNC0646 >98%
  • Packaging100mg
  • Price$986
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146212
  • Product descriptionUNC0646 >98%
  • Packaging250mg
  • Price$1949.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146212
  • Product descriptionUNC0646 >98%
  • Packaging1g
  • Price$3728.1
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11085
  • Product descriptionUNC0646 ≥95%
  • Packaging1mg
  • Price$48
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11085
  • Product descriptionUNC0646 ≥95%
  • Packaging5mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11085
  • Product descriptionUNC0646 ≥95%
  • Packaging10mg
  • Price$210
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11085
  • Product descriptionUNC0646 ≥95%
  • Packaging50mg
  • Price$936
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM295279
  • Product descriptionN-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine 98%
  • Packaging50mg
  • Price$230
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2122
  • Product descriptionUNC0646 99.82%
  • Packaging5mg
  • Price$72
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 4143AH N-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine 10mg $170 2021-12-16 Buy
AK Scientific 4143AH N-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine 50mg $612 2021-12-16 Buy
Ambeed A880677 UNC0646 98+% 5mg $66 2021-12-16 Buy
Ambeed A880677 UNC0646 98+% 10mg $112 2021-12-16 Buy
Ambeed A880677 UNC0646 98+% 25mg $190 2021-12-16 Buy
ApexBio Technology A4504 UNC0646 10mg $92 2021-12-16 Buy
Axon Medchem Axon1840 UNC0646 99% 2x25mg $638 2021-12-16 Buy
Biorbyt Ltd orb146212 UNC0646 >98% 100mg $986 2021-12-16 Buy
Biorbyt Ltd orb146212 UNC0646 >98% 250mg $1949.9 2021-12-16 Buy
Biorbyt Ltd orb146212 UNC0646 >98% 1g $3728.1 2021-12-16 Buy
Cayman Chemical 11085 UNC0646 ≥95% 1mg $48 2024-03-01 Buy
Cayman Chemical 11085 UNC0646 ≥95% 5mg $117 2024-03-01 Buy
Cayman Chemical 11085 UNC0646 ≥95% 10mg $210 2024-03-01 Buy
Cayman Chemical 11085 UNC0646 ≥95% 50mg $936 2024-03-01 Buy
Chemenu CM295279 N-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine 98% 50mg $230 2021-12-16 Buy
ChemScene CS-2122 UNC0646 99.82% 5mg $72 2021-12-16 Buy

Properties

Boiling point :754.6±70.0 °C(Predicted)
Density :1.128±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :9.34±0.70(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

G9a and G9a-like protein (GLP) are euchromatic histone-lysine methyltransferases (EHMT2 and EHMT1, respectively) that can heterodimerize with each other to methylate several proteins in addition to histone H3. UNC0646 is a potent and selective inhibitor of G9a and GLP activities in vitro (IC50s = 6 and 15 nM, respectively) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases. UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line. This compound selectively targets the corepressor function of G9a without affecting its ability to act as a coactivator with glucocorticoid receptor.

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