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ChemicalBook >> CAS DataBase List >> Cabozantinib

Cabozantinib

Cabozantinib price.
  • $7 - $2167
  • Product name: Cabozantinib
  • CAS: 849217-68-1
  • MF: C28H24FN3O5
  • MW: 501.51
  • EINECS:692-846-8
  • MDL Number:MFCD20926324
  • Synonyms:Cabozantinib(XL184Malate);Cabozantinib (XL184, BMS-907351);XL-186;1,1-cyclopropanedicarboxamide, n'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4-fluorophenyl)-;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide Cabozantinib (XL184, BMS-907351);Cabozantinib, >=98%;1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Cabozantinib
41 prices
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  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
Package
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  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-C0755-M010
  • Product descriptionCabozantinib ≥98%(HPLC)
  • Packaging10mg
  • Price$129
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1138-M050
  • Product descriptionCabozantinib ≥95%
  • Packaging50mg
  • Price$497
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1138
  • Product descriptionCabozantinib
  • Packaging10mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1138
  • Product descriptionCabozantinib
  • Packaging100mg
  • Price$845
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging10mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging5mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging50mg
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging100mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging250mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging1g
  • Price$212
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging10g
  • Price$381
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging5g
  • Price$381
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028641
  • Product descriptionCABOZANTINIB 95.00%
  • Packaging10MG
  • Price$716.1
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028641
  • Product descriptionCABOZANTINIB 95.00%
  • Packaging50MG
  • Price$1120.35
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028641
  • Product descriptionCABOZANTINIB 95.00%
  • Packaging200MG
  • Price$2167
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2977
  • Product descriptionCabozantinib(XL184,BMS-907351)
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-C0755-M010 Cabozantinib ≥98%(HPLC) 10mg $129 2021-12-16 Buy
Adipogen Life Sciences SYN-1138-M050 Cabozantinib ≥95% 50mg $497 2021-12-16 Buy
AK Scientific SYN1138 Cabozantinib 10mg $190 2021-12-16 Buy
AK Scientific SYN1138 Cabozantinib 100mg $845 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 10mg $7 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 5mg $7 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 50mg $12 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 100mg $15 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 250mg $65 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 1g $212 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 10g $381 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 5g $381 2021-12-16 Buy
American Custom Chemicals Corporation API0028641 CABOZANTINIB 95.00% 10MG $716.1 2021-12-16 Buy
American Custom Chemicals Corporation API0028641 CABOZANTINIB 95.00% 50MG $1120.35 2021-12-16 Buy
American Custom Chemicals Corporation API0028641 CABOZANTINIB 95.00% 200MG $2167 2021-12-16 Buy
ApexBio Technology A2977 Cabozantinib(XL184,BMS-907351) 5mg $70 2021-12-16 Buy

Properties

Melting point :212-215°C
Boiling point :758.1±60.0 °C(Predicted)
Density :1.396
storage temp. :-20°C
solubility :Soluble in DMSO
form :White powder.
pka :13.86±0.70(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :ONIQOQHATWINJY-UHFFFAOYSA-N
SMILES :C1(C(NC2=CC=C(OC3C4C(N=CC=3)=CC(OC)=C(OC)C=4)C=C2)=O)(C(NC2=CC=C(F)C=C2)=O)CC1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

XL184 is a pan tyrosine kinase inhibitor that primarily targets VEGFR2 (IC50 = 0.035 nM) and c-Met (IC50 = 1.3 nM) but also inhibits RET, c-Kit, Axl, FLT3, and Tie2 (IC50s = 5.2, 4.6, 7, 11.3, and 14.3 nM, respectively). In in vivo breast, lung, and glioma tumor models that represent dysregulated c-Met and VEGFR signaling, XL184 was shown to reduce tumor and endothelial cell proliferation, inhibiting both angiogenesis and metastasis. XL184 has undergone clinical trial in a broad number of cancers, including thyroid carcinoma, prostate cancer, ovarian cancer, melanoma, breast cancer, non-small cell lung cancer, hepatocellular cancer, renal cell carcinoma, and glioblastoma.

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