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ChemicalBook >> CAS DataBase List >> Vandetanib

Vandetanib

Vandetanib price.
  • $6 - $2000
  • Product name: Vandetanib
  • CAS: 443913-73-3
  • MF: C22H24BrFN4O2
  • MW: 475.35
  • EINECS:669-841-4
  • MDL Number:MFCD07772346
  • Synonyms:7-((4-aminocyclohexyl)methoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine;Vandetanib(Zactima),ZD6474;Vandetanib(ZactiMa,AZD6474);Vandetanib base;N-(4-BroMo-2-fluorophenyl)-6-Methoxy-7-[(1-Methylpiperidin-4-yl)Methoxy]-4-aMino-quinazoline;Vandetanib (ZactiMa);ZD6474; ZACTIMA;VANDETANIB
51 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemcia Scientific
  • Chemenu
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 10MG
  • 10mM(in 1mL DMSO)
  • 5mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • 5g
  • 10g
  • 25g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1090-M005
  • Product descriptionVandetanib ≥95%
  • Packaging5mg
  • Price$86
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1090-M100
  • Product descriptionVandetanib ≥95%
  • Packaging100mg
  • Price$421
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95145
  • Product descriptionVandetanib
  • Packaging10g
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126372
  • Product descriptionN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+%
  • Packaging5mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126372
  • Product descriptionN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+%
  • Packaging25mg
  • Price$14
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126372
  • Product descriptionN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+%
  • Packaging50mg
  • Price$22
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126372
  • Product descriptionN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+%
  • Packaging100mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126372
  • Product descriptionN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+%
  • Packaging250mg
  • Price$61
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126372
  • Product descriptionN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+%
  • Packaging1g
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126372
  • Product descriptionN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+%
  • Packaging5g
  • Price$235
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126372
  • Product descriptionN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+%
  • Packaging25g
  • Price$828
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024706
  • Product descriptionVANDETANIB 95.00%
  • Packaging5MG
  • Price$147.4
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024706
  • Product descriptionVANDETANIB 95.00%
  • Packaging10MG
  • Price$225.75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024706
  • Product descriptionVANDETANIB 95.00%
  • Packaging50MG
  • Price$1732.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8555
  • Product descriptionVandetanib(ZD6474)
  • Packaging10mM(in 1mL DMSO)
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS442373
  • Product descriptionN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine ≥98%
  • Packaging25mg
  • Price$14
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1090-M005 Vandetanib ≥95% 5mg $86 2021-12-16 Buy
Adipogen Life Sciences SYN-1090-M100 Vandetanib ≥95% 100mg $421 2021-12-16 Buy
AK Scientific J95145 Vandetanib 10g $400 2021-12-16 Buy
Ambeed A126372 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+% 5mg $6 2021-12-16 Buy
Ambeed A126372 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+% 25mg $14 2021-12-16 Buy
Ambeed A126372 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+% 50mg $22 2021-12-16 Buy
Ambeed A126372 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+% 100mg $35 2021-12-16 Buy
Ambeed A126372 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+% 250mg $61 2021-12-16 Buy
Ambeed A126372 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+% 1g $80 2021-12-16 Buy
Ambeed A126372 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+% 5g $235 2021-12-16 Buy
Ambeed A126372 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 98+% 25g $828 2021-12-16 Buy
American Custom Chemicals Corporation API0024706 VANDETANIB 95.00% 5MG $147.4 2021-12-16 Buy
American Custom Chemicals Corporation API0024706 VANDETANIB 95.00% 10MG $225.75 2021-12-16 Buy
American Custom Chemicals Corporation API0024706 VANDETANIB 95.00% 50MG $1732.5 2021-12-16 Buy
ApexBio Technology A8555 Vandetanib(ZD6474) 10mM(in 1mL DMSO) $80 2021-12-16 Buy
Arctom AS442373 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine ≥98% 25mg $14 2021-12-16 Buy

Properties

Melting point :240-2430C
Boiling point :538.2±50.0 °C(Predicted)
Density :1.406
Flash point :279.3℃
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO (30 mg/ml); Ethanol (10 mg/ml with warming)
pka :8.92±0.10(Predicted)
form :solid
color :White to off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :UHTHHESEBZOYNR-UHFFFAOYSA-N
SMILES :N1=C2C(C=C(OC)C(OCC3CCN(C)CC3)=C2)=C(NC2=CC=C(Br)C=C2F)N=C1
CAS DataBase Reference :443913-73-3

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P370+P378 In case of fire: Use … for extinction.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Vandetanib is a broad spectrum, orally available kinase inhibitor that targets primarily tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR), with IC50 values in the nanomolar range. It also potently blocks non-receptor tyrosine kinases, including ABL, RET, and SRC, as well as several serine/threonine kinases. Primarily because of its effects on receptor tyrosine kinases like VEGFR and EGFR, vandetanib inhibits angiogenesis, cell growth, and metastasis and is effective against certain forms of cancer.

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