pilaralisib
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- $78 - $1060
- Product name: pilaralisib
- CAS: 934526-89-3
- MF: C25H25ClN6O4S
- MW: 541.02
- EINECS:
- MDL Number:MFCD26142605
- Synonyms:PILARALISIB (XL147);SAR245408;XL 147;XL-147,Pilaralisib, SAR245408;XL147(pilaralisib);2-amino-N-[3-[[3-(2-chloro-5-methoxyanilino)quinoxalin-2-yl]sulfamoyl]phenyl]-2-methylpropanamide;2-Amino-N-[3-[N-[3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl]sulfamoyl]phenyl]-2-methylpropanamide;Pilaralisib (XL-147);pilaralisib;Propanamide, 2-amino-N-[3-[[[3-[(2-chloro-5-methoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-2-methyl-
13 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number9609BB
- Product descriptionPilaralisib
- Packaging1g
- Price$1060
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18011
- Product descriptionPilaralisib ≥98%
- Packaging5mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18011
- Product descriptionPilaralisib ≥98%
- Packaging10mg
- Price$153
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18011
- Product descriptionPilaralisib ≥98%
- Packaging25mg
- Price$323
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18011
- Product descriptionPilaralisib ≥98%
- Packaging50mg
- Price$581
- Updated2023-06-20
- Buy
- ManufacturerChemenu
- Product numberCM255870
- Product description2-Amino-N-(3-(N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-2-methylpropanamide 98%
- Packaging50mg
- Price$252
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1546
- Product descriptionPilaralisib 99.57%
- Packaging5mg
- Price$78
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1546
- Product descriptionPilaralisib 99.57%
- Packaging10mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1546
- Product descriptionPilaralisib 99.57%
- Packaging50mg
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000195
- Product descriptionXL-147 98+%
- Packaging50mg
- Price$385
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8184
- Product descriptionPilaralisib(XL-147;SAR245408) >98%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number98511
- Product descriptionPilaralisib
- Packaging5mg
- Price$405
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberP441390
- Product descriptionPilaralisib
- Packaging10mg
- Price$120
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 9609BB | Pilaralisib | 1g | $1060 | 2021-12-16 | Buy |
| Cayman Chemical | 18011 | Pilaralisib ≥98% | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 18011 | Pilaralisib ≥98% | 10mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 18011 | Pilaralisib ≥98% | 25mg | $323 | 2024-03-01 | Buy |
| Cayman Chemical | 18011 | Pilaralisib ≥98% | 50mg | $581 | 2023-06-20 | Buy |
| Chemenu | CM255870 | 2-Amino-N-(3-(N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-2-methylpropanamide 98% | 50mg | $252 | 2021-12-16 | Buy |
| ChemScene | CS-1546 | Pilaralisib 99.57% | 5mg | $78 | 2021-12-16 | Buy |
| ChemScene | CS-1546 | Pilaralisib 99.57% | 10mg | $132 | 2021-12-16 | Buy |
| ChemScene | CS-1546 | Pilaralisib 99.57% | 50mg | $336 | 2021-12-16 | Buy |
| Crysdot | CD31000195 | XL-147 98+% | 50mg | $385 | 2021-12-16 | Buy |
| DC Chemicals | DC8184 | Pilaralisib(XL-147;SAR245408) >98% | 100mg | $450 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 98511 | Pilaralisib | 5mg | $405 | 2021-12-16 | Buy |
| TRC | P441390 | Pilaralisib | 10mg | $120 | 2021-12-16 | Buy |
Properties
Melting point :216-220oC
Density :1.458±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly)
pka :6.33±0.30(Predicted)
form :Solid
color :Light Yellow to Yellow
Density :1.458±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly)
pka :6.33±0.30(Predicted)
form :Solid
color :Light Yellow to Yellow
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival. Pilaralisib is a methylbenzenesulfonamide derivative that reversibly inhibits class I PI3Ks (IC50s = 39, 36, 23, and 383 nM for p110α, -δ, -γ, and -β, respectively). It has been shown to abrogate Akt and S6 kinase phosphorylation, reduce cyclin D1 and retinoblastoma protein, and upregulate the CDK inhibitor p27, inhibiting cell proliferation. In HER2-overexpressing breast cancer cells, cotreatment with the HER2 inhibitors trastuzumab or lapatinib are reported to sensitize tumor cells to the growth inhibitory effect of pilaralisib. This compound has been evaluated in clinical trials in patients with advanced solid tumors.Related product price
- XL147
$32-2097.8 - XL019
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$45-1802
