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ChemicalBook >> CAS DataBase List >> BMS 833923

BMS 833923

BMS 833923 price.
  • $45 - $1802
  • Product name: BMS 833923
  • CAS: 1059734-66-5
  • MF: C30H27N5O
  • MW: 473.57
  • EINECS:
  • MDL Number:MFCD25976660
  • Synonyms:BMS 833923;XL 139;XL139;XL-139;BMS-833923 (XL-139);N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide;Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-;BMS 833923 N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide
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  • AK Scientific
  • ApexBio Technology
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  • ManufacturerAK Scientific
  • Product number2281AH
  • Product descriptionBMS-833923
  • Packaging10mg
  • Price$162
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3258
  • Product descriptionBMS-833923
  • Packaging5mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3258
  • Product descriptionBMS-833923
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3258
  • Product descriptionBMS-833923
  • Packaging50mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180855
  • Product descriptionBMS-833923 (XL-139) >98%
  • Packaging100mg
  • Price$606.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180855
  • Product descriptionBMS-833923 (XL-139) >98%
  • Packaging1000mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16240
  • Product descriptionBMS 833923 ≥98%
  • Packaging5mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16240
  • Product descriptionBMS 833923 ≥98%
  • Packaging10mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16240
  • Product descriptionBMS 833923 ≥98%
  • Packaging25mg
  • Price$194
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number16240
  • Product descriptionBMS 833923 ≥98%
  • Packaging50mg
  • Price$317
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM142373
  • Product descriptionN-(2-Methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide 98%
  • Packaging100mg
  • Price$409
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-1464
  • Product descriptionBMS-833923 98.21%
  • Packaging10mg
  • Price$92
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-1464
  • Product descriptionBMS-833923 98.21%
  • Packaging50mg
  • Price$256
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-1464
  • Product descriptionBMS-833923 98.21%
  • Packaging100mg
  • Price$455
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004681
  • Product descriptionBMS-833923 98+%
  • Packaging50mg
  • Price$227
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004681
  • Product descriptionBMS-833923 98+%
  • Packaging100mg
  • Price$403
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2281AH BMS-833923 10mg $162 2021-12-16 Buy
ApexBio Technology A3258 BMS-833923 5mg $45 2021-12-16 Buy
ApexBio Technology A3258 BMS-833923 10mg $70 2021-12-16 Buy
ApexBio Technology A3258 BMS-833923 50mg $200 2021-12-16 Buy
Biorbyt Ltd orb180855 BMS-833923 (XL-139) >98% 100mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb180855 BMS-833923 (XL-139) >98% 1000mg $1802 2021-12-16 Buy
Cayman Chemical 16240 BMS 833923 ≥98% 5mg $62 2024-03-01 Buy
Cayman Chemical 16240 BMS 833923 ≥98% 10mg $109 2024-03-01 Buy
Cayman Chemical 16240 BMS 833923 ≥98% 25mg $194 2024-03-01 Buy
Cayman Chemical 16240 BMS 833923 ≥98% 50mg $317 2024-03-01 Buy
Chemenu CM142373 N-(2-Methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide 98% 100mg $409 2021-12-16 Buy
ChemScene CS-1464 BMS-833923 98.21% 10mg $92 2021-12-16 Buy
ChemScene CS-1464 BMS-833923 98.21% 50mg $256 2021-12-16 Buy
ChemScene CS-1464 BMS-833923 98.21% 100mg $455 2021-12-16 Buy
Crysdot CD31004681 BMS-833923 98+% 50mg $227 2021-12-16 Buy
Crysdot CD31004681 BMS-833923 98+% 100mg $403 2021-12-16 Buy

Properties

Density :1.252±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥47.4 mg/mL in DMSO; insoluble in H2O; ≥5.14 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :13.42±0.70(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.

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