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ChemicalBook >> CAS DataBase List >> PFK-015

PFK-015

PFK-015 price.
  • $44 - $2499
  • Product name: PFK-015
  • CAS: 4382-63-2
  • MF: C17H12N2O
  • MW: 260.29
  • EINECS:
  • MDL Number:MFCD28099813
  • Synonyms:2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15;1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one;PFK-015;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;PFK015;PFK15;PFK 15;PFK-15;CS-1317;PFK15 (PFK-015)
18 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • Arctom
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5216
  • Product descriptionPFK15
  • Packaging100mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131123
  • Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+%
  • Packaging5mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131123
  • Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+%
  • Packaging10mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131123
  • Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+%
  • Packaging50mg
  • Price$227
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131123
  • Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+%
  • Packaging100mg
  • Price$294
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA131123
  • Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+%
  • Packaging1g
  • Price$2499
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS445368
  • Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one ≥98%
  • Packaging100mg
  • Price$291
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17689
  • Product descriptionPFK15 ≥95%
  • Packaging5mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17689
  • Product descriptionPFK15 ≥95%
  • Packaging10mg
  • Price$75
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17689
  • Product descriptionPFK15 ≥95%
  • Packaging25mg
  • Price$165
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17689
  • Product descriptionPFK15 ≥95%
  • Packaging50mg
  • Price$264
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001902
  • Product descriptionPFK-015 98+%
  • Packaging50mg
  • Price$278
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001902
  • Product descriptionPFK-015 98+%
  • Packaging100mg
  • Price$507
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8026
  • Product descriptionPFK-015 >98%
  • Packaging100mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8026
  • Product descriptionPFK-015 >98%
  • Packaging250mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1009
  • Product descriptionPFK15 ≥98% (HPLC)
  • Packaging25mg
  • Price$476
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5216 PFK15 100mg $650 2021-12-16 Buy
Ambeed A131123 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+% 5mg $104 2021-12-16 Buy
Ambeed A131123 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+% 10mg $135 2021-12-16 Buy
Ambeed A131123 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+% 50mg $227 2021-12-16 Buy
Ambeed A131123 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+% 100mg $294 2021-12-16 Buy
Ambeed A131123 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+% 1g $2499 2021-12-16 Buy
Arctom AS445368 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one ≥98% 100mg $291 2021-12-16 Buy
Cayman Chemical 17689 PFK15 ≥95% 5mg $44 2024-03-01 Buy
Cayman Chemical 17689 PFK15 ≥95% 10mg $75 2024-03-01 Buy
Cayman Chemical 17689 PFK15 ≥95% 25mg $165 2024-03-01 Buy
Cayman Chemical 17689 PFK15 ≥95% 50mg $264 2024-03-01 Buy
Crysdot CD31001902 PFK-015 98+% 50mg $278 2021-12-16 Buy
Crysdot CD31001902 PFK-015 98+% 100mg $507 2021-12-16 Buy
DC Chemicals DC8026 PFK-015 >98% 100mg $250 2021-12-16 Buy
DC Chemicals DC8026 PFK-015 >98% 250mg $450 2021-12-16 Buy
Sigma-Aldrich SML1009 PFK15 ≥98% (HPLC) 25mg $476 2024-03-01 Buy

Properties

Boiling point :464.4±45.0 °C(Predicted)
Density :1.237±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :3.11±0.61(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) is a bifunctional enzyme that contains distinct domains for the phosphorylation of fructose 6-phosphate and the dephosphorylation of fructose 2,6-bisphosphate. PFKFB3 protein expression is elevated in most tumor types. PFK15 is a selective inhibitor of PFKFB3 (IC50 = 207 nM). It has no significant inhibitory effect on any member of a panel of 96 other kinases, and does not inhibit purified 6-phosphofructo-1-kinase, hexokinase, phosphoglucose isomerase, or PFKFB4. PFK15 rapidly induces apoptosis in transformed cells, suppresses glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and yields antitumor effects in human xenograft models of cancer in athymic mice.

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