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ChemicalBook >> CAS DataBase List >> CCT 137690

CCT 137690

CCT 137690 price.
  • $55 - $979
  • Product name: CCT 137690
  • CAS: 1095382-05-0
  • MF: C26H31BrN8O
  • MW: 551.48
  • EINECS:
  • MDL Number:MFCD18206879
  • Synonyms:CCT 137690;6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridine;3-[[4-[6-Bromo-2-[4-(4-methylpiperazin-1-yl)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]methyl]-5-methylisoxazole CCT-137690;CCT137690, >=98%;3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-;6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine;CS-56;CCT-137690; CCT137690
29 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mM(in 1mL DMSO)
  • 5mg
  • 10
  • 2mg
  • 50
  • 10mg
  • 2x10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product numberY0286
  • Product descriptionCCT137690
  • Packaging10mg
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA917251
  • Product descriptionCCT137690 98+%
  • Packaging100mg
  • Price$965
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA917251
  • Product descriptionCCT137690 98+%
  • Packaging50mg
  • Price$502
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA917251
  • Product descriptionCCT137690 98+%
  • Packaging25mg
  • Price$336
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA917251
  • Product descriptionCCT137690 98+%
  • Packaging10mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA917251
  • Product descriptionCCT137690 98+%
  • Packaging5mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA917251
  • Product descriptionCCT137690 98+%
  • Packaging2mg
  • Price$63
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001360
  • Product descriptionCCT-137690 95.00%
  • Packaging10MG
  • Price$289.8
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4132
  • Product descriptionCCT137690
  • Packaging10mM(in 1mL DMSO)
  • Price$103
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1836
  • Product descriptionCCT137690 98%
  • Packaging2x10mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1836
  • Product descriptionCCT137690 98%
  • Packaging50mg
  • Price$478.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15552
  • Product descriptionCCT137690 ≥98%
  • Packaging5mg
  • Price$110
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15552
  • Product descriptionCCT137690 ≥98%
  • Packaging10mg
  • Price$142
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15552
  • Product descriptionCCT137690 ≥98%
  • Packaging50mg
  • Price$648
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM151434
  • Product description3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole 98%
  • Packaging100mg
  • Price$495
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0706
  • Product descriptionCCT137690 99.10%
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y0286 CCT137690 10mg $220 2021-12-16 Buy
Ambeed A917251 CCT137690 98+% 100mg $965 2021-12-16 Buy
Ambeed A917251 CCT137690 98+% 50mg $502 2021-12-16 Buy
Ambeed A917251 CCT137690 98+% 25mg $336 2021-12-16 Buy
Ambeed A917251 CCT137690 98+% 10mg $138 2021-12-16 Buy
Ambeed A917251 CCT137690 98+% 5mg $96 2021-12-16 Buy
Ambeed A917251 CCT137690 98+% 2mg $63 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001360 CCT-137690 95.00% 10MG $289.8 2021-12-16 Buy
ApexBio Technology A4132 CCT137690 10mM(in 1mL DMSO) $103 2021-12-16 Buy
Axon Medchem Axon1836 CCT137690 98% 2x10mg $176 2021-12-16 Buy
Axon Medchem Axon1836 CCT137690 98% 50mg $478.5 2021-12-16 Buy
Cayman Chemical 15552 CCT137690 ≥98% 5mg $110 2024-03-01 Buy
Cayman Chemical 15552 CCT137690 ≥98% 10mg $142 2024-03-01 Buy
Cayman Chemical 15552 CCT137690 ≥98% 50mg $648 2024-03-01 Buy
Chemenu CM151434 3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole 98% 100mg $495 2021-12-16 Buy
ChemScene CS-0706 CCT137690 99.10% 5mg $85 2021-12-16 Buy

Properties

Density :1.424
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥6.89 mg/mL in DMSO
form :solid
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CCT137690 is a potent inhibitor of Aurora kinases (IC50s = 15, 25 and 19 nM for Aurora A, B, and C, respectively). It also inhibits the receptor tyrosine kinase FLT3 as well as the constitutively active form of FLT3 bearing internal-tandem duplications (FLT3-ITD; IC50s = 1.2 and 4.9 nM, respectively). CCT137690 is orally bioavailable, inhibiting the growth of SW620 colon carcinoma xenografts in mice without inducing body weight loss. It blocks signaling through Aurora kinases in MYCN-amplified neuroblastoma cells, suppressing N-Myc expression and preventing proliferation. It inhibits growth of FLT3-ITD cells harboring a D835Y mutation, which confers resistance to other FLT3 inhibitors. CCT137690 also sensitizes colorectal carcinoma cells to radiotherapy.

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