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ChemicalBook >> CAS DataBase List >> 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide

4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide

4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide price.
  • $47 - $8326
  • Product name: 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
  • CAS: 188591-46-0
  • MF: C15H12ClF3N2O3S
  • MW: 392.78
  • EINECS:
  • MDL Number:MFCD00099612
  • Synonyms:4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide;GSK 3787;GSK3787/GSK-3787;Benzamide, 4-chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-;4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-benzamide GSK 3787;4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide;4-chloro-N-(2-(5-(trifluoromethyl)pyridin-2-ylsulfonyl)ethyl)benzamide;GSK3787;GSK 3787;GSK-3787
29 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 5mg
  • 10mg
  • 10
  • 25mg
  • 50mg
  • 100mg
  • 10mM(in 1mL DMSO)
  • 250mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product numberY0453
  • Product description4-Chloro-N-[2-[[5-(trifluoromethyl-2-pyridinyl]sulfonyl]ethyl]benzamide
  • Packaging25mg
  • Price$224
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA575893
  • Product descriptionGSK3787 98+%
  • Packaging5mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA575893
  • Product descriptionGSK3787 98+%
  • Packaging10mg
  • Price$155
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA575893
  • Product descriptionGSK3787 98+%
  • Packaging25mg
  • Price$232
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA575893
  • Product descriptionGSK3787 98+%
  • Packaging50mg
  • Price$348
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA575893
  • Product descriptionGSK3787 98+%
  • Packaging100mg
  • Price$521
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA575893
  • Product descriptionGSK3787 98+%
  • Packaging250mg
  • Price$833
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberMTB0000021
  • Product descriptionGSK3787 95.00%
  • Packaging10MG
  • Price$710.33
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberMTB0000021
  • Product descriptionGSK3787 95.00%
  • Packaging50MG
  • Price$1056.83
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4303
  • Product descriptionGSK3787
  • Packaging10mM(in 1mL DMSO)
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15219
  • Product descriptionGSK3787 ≥95%
  • Packaging5mg
  • Price$47
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15219
  • Product descriptionGSK3787 ≥95%
  • Packaging10mg
  • Price$73
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15219
  • Product descriptionGSK3787 ≥95%
  • Packaging25mg
  • Price$160
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15219
  • Product descriptionGSK3787 ≥95%
  • Packaging50mg
  • Price$250
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM176447
  • Product description4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide 98%
  • Packaging50mg
  • Price$226
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1262
  • Product descriptionGSK3787 99.04%
  • Packaging10mg
  • Price$106
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y0453 4-Chloro-N-[2-[[5-(trifluoromethyl-2-pyridinyl]sulfonyl]ethyl]benzamide 25mg $224 2021-12-16 Buy
Ambeed A575893 GSK3787 98+% 5mg $104 2021-12-16 Buy
Ambeed A575893 GSK3787 98+% 10mg $155 2021-12-16 Buy
Ambeed A575893 GSK3787 98+% 25mg $232 2021-12-16 Buy
Ambeed A575893 GSK3787 98+% 50mg $348 2021-12-16 Buy
Ambeed A575893 GSK3787 98+% 100mg $521 2021-12-16 Buy
Ambeed A575893 GSK3787 98+% 250mg $833 2021-12-16 Buy
American Custom Chemicals Corporation MTB0000021 GSK3787 95.00% 10MG $710.33 2021-12-16 Buy
American Custom Chemicals Corporation MTB0000021 GSK3787 95.00% 50MG $1056.83 2021-12-16 Buy
ApexBio Technology A4303 GSK3787 10mM(in 1mL DMSO) $97 2021-12-16 Buy
Cayman Chemical 15219 GSK3787 ≥95% 5mg $47 2024-03-01 Buy
Cayman Chemical 15219 GSK3787 ≥95% 10mg $73 2024-03-01 Buy
Cayman Chemical 15219 GSK3787 ≥95% 25mg $160 2024-03-01 Buy
Cayman Chemical 15219 GSK3787 ≥95% 50mg $250 2024-03-01 Buy
Chemenu CM176447 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide 98% 50mg $226 2021-12-16 Buy
ChemScene CS-1262 GSK3787 99.04% 10mg $106 2021-12-16 Buy

Properties

Boiling point :585.1±50.0 °C(Predicted)
Density :1.448±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
pka :12.92±0.46(Predicted)
form :White solid
color :white to off-white
Stability :Stable for 1 year for up to year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :188591-46-0

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PPARβ/δ is thought to play a role in lipid homeostasis and glucose disposal by regulating genes involved in fatty acid oxidation, reverse cholesterol transport, and carbon substrate utilization in skeletal muscle. It has also been implicated in the progression of certain cancers. GSK3787 is an irreversible antagonist of PPARβ/δ (pIC50 = 6.6) with no measurable affinity for PPARα or PPARγ (pIC50 >5). At 1μM, it inhibits the expression of PPARβ/δ-regulated target genes, pyruvate dehydrogenase kinase 4 and carnitine palmitoyl transferase 1a, which are important for energy homeostasis in human skeletal muscle cells. GSK3787 (at 1 μM) also antagonizes agonist-induced expression of angiopoietin-like protein 4 in mouse fibroblasts, mouse keratinocytes, and human MCF-7, Huh7, and HepG2 cancer cell lines.

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