KL001
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- $68 - $1158
- Product name: KL001
- CAS: 309928-48-1
- MF: C21H22N2O4S
- MW: 398.48
- EINECS:
- MDL Number:MFCD02086647
- Synonyms:N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide;N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide;Methanesulfonamide, N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-;KL001(KL-001;Inhibitor,inhibit,stabilizer,KL001,circadian,cryptochrome,ubiquitin,period,gluconeogenesis,CRY;KL001(KL-001,KL 001);KL001, 10 mM in DMSO
19 prices
Selected condition：
Brand
- AK Scientific
- Alichem
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 2mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number4099CJ
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide
- Packaging2mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number309928481
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide
- Packaging50mg
- Price$1091.8
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCBL0015791
- Product descriptionN-[3-(9H-CARBAZOL-9-YL)-2-HYDROXYPROPYL]-N-(2-FURANYLMETHYL)-METHANESULFONAMIDE 95.00%
- Packaging5MG
- Price$453.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5684
- Product descriptionKL001
- Packaging10mg
- Price$282
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5684
- Product descriptionKL001
- Packaging50mg
- Price$1158
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK167145
- Product descriptionKL 001
- Packaging1mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK167145
- Product descriptionKL 001
- Packaging2mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK167145
- Product descriptionKL 001
- Packaging5mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK167145
- Product descriptionKL 001
- Packaging10mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13878
- Product descriptionKL001 ≥98%
- Packaging5mg
- Price$68
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13878
- Product descriptionKL001 ≥98%
- Packaging10mg
- Price$121
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13878
- Product descriptionKL001 ≥98%
- Packaging25mg
- Price$235
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD11148162
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 97%
- Packaging50mg
- Price$1030
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC23779
- Product descriptionKL001(KL-001;KL001) >98%
- Packaging100mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number59388
- Product descriptionKL001
- Packaging5mg
- Price$610
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number59388
- Product descriptionKL001
- Packaging50mg
- Price$825
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4099CJ | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide | 2mg | $218 | 2021-12-16 | Buy |
| Alichem | 309928481 | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide | 50mg | $1091.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0015791 | N-[3-(9H-CARBAZOL-9-YL)-2-HYDROXYPROPYL]-N-(2-FURANYLMETHYL)-METHANESULFONAMIDE 95.00% | 5MG | $453.9 | 2021-12-16 | Buy |
| ApexBio Technology | B5684 | KL001 | 10mg | $282 | 2021-12-16 | Buy |
| ApexBio Technology | B5684 | KL001 | 50mg | $1158 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK167145 | KL 001 | 1mg | $80 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK167145 | KL 001 | 2mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK167145 | KL 001 | 5mg | $200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK167145 | KL 001 | 10mg | $350 | 2021-12-16 | Buy |
| Cayman Chemical | 13878 | KL001 ≥98% | 5mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 13878 | KL001 ≥98% | 10mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 13878 | KL001 ≥98% | 25mg | $235 | 2024-03-01 | Buy |
| Crysdot | CD11148162 | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 97% | 50mg | $1030 | 2021-12-16 | Buy |
| DC Chemicals | DC23779 | KL001(KL-001;KL001) >98% | 100mg | $750 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 59388 | KL001 | 5mg | $610 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 59388 | KL001 | 50mg | $825 | 2021-12-16 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
solubility :DMSO: soluble20mg/mL, clear
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The cryptochrome proteins CRY1 and CRY2, which play central roles in maintaining the circadian clock, are expressed and then degraded in a rhythmic pattern. KL001 is a cell-permeable carbazolic compound which directly interacts with and stabilizes CRY1 and CRY2, preventing ubiquitin-dependent degradation while lengthening the circadian period (IC50 = 0.82-14 μM). As the expression of some gluconeogenic genes is both circadian and cryptochrome-dependent, KL001 effectively inhibits glucagon-induced gluconeogenesis in primary hepatocytes. This product can be used to study the regulation of cryptochrome-dependent physiology and aid in the development of clock-based therapeutics of diabetes.Related product price
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Sigma-Aldrich
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