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ChemicalBook >> CAS DataBase List >> GSK-3326595

GSK-3326595

GSK-3326595 price.
  • $32 - $2182
  • Product name: GSK-3326595
  • CAS: 1616392-22-3
  • MF: C24H32N6O3
  • MW: 452.55
  • EINECS:
  • MDL Number:MFCD29991177
  • Synonyms:EPZ-015938;4-Pyrimidinecarboxamide, 6-[(1-acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-;GSK-3326595,EPZ-015938;EPZ-015938 (GSK3326595);4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamid;6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1;EPZ015938; 6-[(1-ACETYLPIPERIDIN-4-YL)AMINO]-N-[(2S)-2-HYDROXY-3-(1;2;3;4-TETRAHYDROISOQUINOLIN-2-YL)PROPYL]PYRIMIDINE-4-CARBOXAMID;EPZ015938; EPZ 015938; EPZ-015938
26 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • Ambeed
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3298EB
  • Product descriptionCID90241742
  • Packaging1g
  • Price$2182
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1616392223
  • Product description(S)-6-((1-Acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide
  • Packaging1g
  • Price$1498
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA416840
  • Product descriptionGSK3326595 98%
  • Packaging5mg
  • Price$38
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA416840
  • Product descriptionGSK3326595 98%
  • Packaging10mg
  • Price$69
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA416840
  • Product descriptionGSK3326595 98%
  • Packaging25mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA416840
  • Product descriptionGSK3326595 98%
  • Packaging50mg
  • Price$186
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA416840
  • Product descriptionGSK3326595 98%
  • Packaging100mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA416840
  • Product descriptionGSK3326595 98%
  • Packaging250mg
  • Price$589
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA416840
  • Product descriptionGSK3326595 98%
  • Packaging1g
  • Price$1572
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0066055
  • Product description6-[(1-ACETYLPIPERIDIN-4-YL)AMINO]-N-[(2S)-2-HYDROXY-3-(1,2,3,4-TETRAHYDROISOQUINOLIN-2-YL)PROPYL]PYRIMIDINE-4-CARBOXAMIDE 95.00%
  • Packaging5MG
  • Price$454.46
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number27305
  • Product descriptionGSK3326595
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27305
  • Product descriptionGSK3326595
  • Packaging5mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27305
  • Product descriptionGSK3326595
  • Packaging10mg
  • Price$199
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27305
  • Product descriptionGSK3326595
  • Packaging25mg
  • Price$343
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM268117
  • Product description(S)-6-((1-Acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide 97%
  • Packaging1g
  • Price$1244
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6451
  • Product descriptionGSK3326595 99.55%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3298EB CID90241742 1g $2182 2021-12-16 Buy
Alichem 1616392223 (S)-6-((1-Acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide 1g $1498 2021-12-16 Buy
Ambeed A416840 GSK3326595 98% 5mg $38 2021-12-16 Buy
Ambeed A416840 GSK3326595 98% 10mg $69 2021-12-16 Buy
Ambeed A416840 GSK3326595 98% 25mg $133 2021-12-16 Buy
Ambeed A416840 GSK3326595 98% 50mg $186 2021-12-16 Buy
Ambeed A416840 GSK3326595 98% 100mg $360 2021-12-16 Buy
Ambeed A416840 GSK3326595 98% 250mg $589 2021-12-16 Buy
Ambeed A416840 GSK3326595 98% 1g $1572 2021-12-16 Buy
American Custom Chemicals Corporation CCH0066055 6-[(1-ACETYLPIPERIDIN-4-YL)AMINO]-N-[(2S)-2-HYDROXY-3-(1,2,3,4-TETRAHYDROISOQUINOLIN-2-YL)PROPYL]PYRIMIDINE-4-CARBOXAMIDE 95.00% 5MG $454.46 2021-12-16 Buy
Cayman Chemical 27305 GSK3326595 1mg $32 2024-03-01 Buy
Cayman Chemical 27305 GSK3326595 5mg $116 2024-03-01 Buy
Cayman Chemical 27305 GSK3326595 10mg $199 2024-03-01 Buy
Cayman Chemical 27305 GSK3326595 25mg $343 2024-03-01 Buy
Chemenu CM268117 (S)-6-((1-Acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide 97% 1g $1244 2021-12-16 Buy
ChemScene CS-6451 GSK3326595 99.55% 5mg $50 2021-12-16 Buy

Properties

Boiling point :760.3±60.0 °C(Predicted)
Density :1.275±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 20 mg/ml).
pka :12.44±0.46(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

GSK3326595 (1616395-22-3) is a potent (IC50?= 6.2nM), selective (>4000-fold over 20 other methyltransferases), SAM uncompetitive, peptide competitive inhibitor of PRMT5.1?PRMT5 inhibition activated the p53 pathway?via?induction of alternative splicing of MDM4 leading to a potent anti-proliferative response both?in vitro?and?in vivo. Combination therapy with palbociclib (CDK4/6 inhibitor, Focus Cat.# 10-4760) and GSK3326595 lead to increased efficacy of palbociclib in treating native and resistant models of melanoma via regulation of the PRMT5-MDM4 axis.2?Currently in clinical trials.3

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