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Analytical Chemistry

Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure Chemical Name CAS MF
Rocuronium Bromide Impurity 9 Rocuronium Bromide Impurity 9
Adefovir Impurity 6 Adefovir Impurity 6
Apremilast Impurity QY Apremilast Impurity QY
Dextrorotation lansoprazole Impurity J Dextrorotation lansoprazole Impurity J
Dextrorotation lansoprazole-N-oxide Dextrorotation lansoprazole-N-oxide
lansoprazole Impurity 23 lansoprazole Impurity 23
lansoprazole Impurity 29 lansoprazole Impurity 29
Loratadine Impurity L Loratadine Impurity L C22H23ClN2O2
meta-dyhydroxy Sugammadex sodium Impurity 1 meta-dyhydroxy Sugammadex sodium Impurity 1
Olanzapine impurity R Olanzapine impurity R C17H20N4S
Palbociclib Impurity 33 Palbociclib Impurity 33
Pramipexole Related Impurity 1 Pramipexole Related Impurity 1
Ropivacaine Impurity 37 Ropivacaine Impurity 37
Ropivacaine Impurity 42 Ropivacaine Impurity 42
Sugammadex sodium Org197339-1 Impurity Sugammadex sodium Org197339-1 Impurity
Fludarabine EP impurity G Fludarabine EP impurity G 548774-56-7 C10H12ClFN5O6P
Sitagliptin Impurity 12 Sitagliptin Impurity 12 1803026-54-1 C16H12F6N4O
Afatinib impurity 30 Afatinib impurity 30
Avibactam Impurity 45 Avibactam Impurity 45 2064219-20-9 C23H46N4O6S
Butyphthalide impurity 44 Butyphthalide impurity 44 952413-01-3 C13H18O3
Cabozantinib impurity 24 Cabozantinib impurity 24
Celecoxib Impurity 18 Celecoxib Impurity 18 2271123-54-5 C11H9F3O2
Dapoxetine impurity 22 Dapoxetine impurity 22
Febuxostat Impurity 85 Febuxostat Impurity 85
Fosaprepitant Impurity NLS Fosaprepitant Impurity NLS
Irinotecan Impurity 17 HCl Irinotecan Impurity 17 HCl 1332610-75-9 C19H14N2O4
LCZ696(valsartan + sacubitril) impurity 31 LCZ696(valsartan + sacubitril) impurity 31
Lenvatinib Impurity 24 Lenvatinib Impurity 24
Lenvatinib Impurity 30 Lenvatinib Impurity 30
Regorafenib Impurity 22 Regorafenib Impurity 22
Regorafenib Impurity 28 Regorafenib Impurity 28
Sitafloxacin Impurity ZZ-C-01 Sitafloxacin Impurity ZZ-C-01
Tofacitinib Impurity 85 Tofacitinib Impurity 85 2268720-86-9 C20H24ClN5
Tofacitinib Impurity 90 Tofacitinib Impurity 90
Nintedanib Impurity M Nintedanib Impurity M
Citalopram Impurity 14 Citalopram Impurity 14 1470362-85-6 C20H23FN2O2
Eltrombopag Impurity 8 Eltrombopag Impurity 8
Vitexin 2''-O-beta-D-glucoside Vitexin 2''-O-beta-D-glucoside 61360-94-9 C27H30O15
Capecitabine impurity 6 Capecitabine impurity 6
Vilanterol Impurity 25 Vilanterol Impurity 25 1027529-99-2 C13H15NO4
Cefdinir Impurity Cefdinir Impurity
Sugammadex sodium Org139131-1 Impurity Sugammadex sodium Org139131-1 Impurity
Dolutegravir Impurity 16 Dolutegravir Impurity 16 1357289-37-2 C20H19F2N3O5
N - hydroxy Tropisetron Impurity 2 N - hydroxy Tropisetron Impurity 2
Tofacitinib Impurity 98 Tofacitinib Impurity 98
Cabozantinib impurity 30 Cabozantinib impurity 30
Cabozantinib impurity 35 Cabozantinib impurity 35 1905820-17-8
Carvedilol Impurity DBA Carvedilol Impurity DBA 3258-70-6 C18H23NO4
Pregabalin Impurity 9 Pregabalin Impurity 9 44855-96-1 C5H7NO3
Butyphthalide impurity 50 Butyphthalide impurity 50
Canagliflozin Impurity 40 Canagliflozin Impurity 40
Pralatrexate Impurity 4 Pralatrexate Impurity 4 1445586-42-4 C18H15N5O3
Pralatrexate Impurity 9 Pralatrexate Impurity 9 1548618-61-6 C23H22N6O6
Pitavastatin Impurity 47 Pitavastatin Impurity 47
Lenvatinib Impurity 38 Lenvatinib Impurity 38
Tazobactam Impurity 9 Tazobactam Impurity 9
Doxofylline Impurity 11 Doxofylline Impurity 11 109403-76-1 C15H16N8O4
Doxofylline Impurity 14 Doxofylline Impurity 14
Canagliflozin Impurity 56 Canagliflozin Impurity 56
Canagliflozin Impurity 61 Canagliflozin Impurity 61
Tofacitinib Impurity 107 Tofacitinib Impurity 107
Hydroxychloroquine Impurity K Hydroxychloroquine Impurity K
Levosimendan Impurity 8 Levosimendan Impurity 8 274263-65-9 C14H14N6O2
Cabozantinib impurity R Cabozantinib impurity R
Rotigotine Impurity 4 Rotigotine Impurity 4
Crisaborole Impurity 4 Crisaborole Impurity 4
Crisaborole Impurity 9 Crisaborole Impurity 9
Trifluridine Impurity C Trifluridine Impurity C
Olprinone Impurity 3 Olprinone Impurity 3 1402751-73-8 C14H11N3O3
Olprinone Impurity 8 Olprinone Impurity 8
(R)-9-fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride (R)-9-fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride 117707-39-8 C17H18FN3O4
Nicorandil Impurity G Nicorandil Impurity G
Bivalirudin Impurity 3 Bivalirudin Impurity 3 1310025-28-5 C98H138N24O33
Cilastatin Impurity 3 Cilastatin Impurity 3
Solifenacin Impurity 7(Solifenacin EP Impurity D) Solifenacin Impurity 7(Solifenacin EP Impurity D) 2216750-52-4 C31H28N2O
Dyclonine Impurity 2 Dyclonine Impurity 2 66536-15-0 C13H16O2
Cefuroxime Impurity 33 Cefuroxime Impurity 33 929531-94-2 C16H16N4O9S
Ondansetron IMpurity 4 Ondansetron IMpurity 4
MeropeneM iMpurity 3 MeropeneM iMpurity 3
MeropeneM iMpurity 8 MeropeneM iMpurity 8
Metronidazole Impurity 13 Metronidazole Impurity 13 110578-73-9 C6H9N3O3
Eletriptan Impurity 4 Eletriptan Impurity 4 1422285-51-5 C44H50N4O4S2
Afatinib Impurity 51 Afatinib Impurity 51
Afatinib Impurity 51 Afatinib Impurity 51
Afatinib Impurity 66 Afatinib Impurity 66
Afatinib Impurity 66 Afatinib Impurity 66
Brivaracetam Impurity 10 Brivaracetam Impurity 10 60559-16-2 C10H20O2
Cabozantinib Impurity 6 Cabozantinib Impurity 6
Empagliflozin Impurity 59 Empagliflozin Impurity 59
Fulvestrant Impurity 12 Fulvestrant Impurity 12
Linagliptin Impurity 56 Linagliptin Impurity 56
Linagliptin Impurity 61 Linagliptin Impurity 61
Ornidazole Impurity 16 Ornidazole Impurity 16 1565482-62-3 C7H11ClN2O
Oseltamivir Impurity 46 Oseltamivir Impurity 46
Oseltamivir Impurity 53 Oseltamivir Impurity 53
Palbociclib Impurity 66 Palbociclib Impurity 66
Peramivir Impurity 13 Peramivir Impurity 13 2641684-79-7 C13H27ClN4O3
Pimecrolimus Impurity 2 Pimecrolimus Impurity 2
Rosuvastatin Impurity 81 Rosuvastatin Impurity 81
Rosuvastatin Impurity 102 Rosuvastatin Impurity 102
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