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Analytical Chemistry

Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure Chemical Name CAS MF
Aprepitant Impurity 14 Aprepitant Impurity 14
Trelagliptin Impurity 16 Trelagliptin Impurity 16
Decitabine Impurity 7 Decitabine Impurity 7
Fosaprepitant Impurity 6 Fosaprepitant Impurity 6
Dapoxetine Impurity 6 Dapoxetine Impurity 6
Regorafenib Impurity 13 Regorafenib Impurity 13
Topiroxostat Impurity 4 Topiroxostat Impurity 4
Bosutinib Impurity 8 Bosutinib Impurity 8
Ticagrelor Impurity 13 Ticagrelor Impurity 13
Ticagrelor Impurity 66 Ticagrelor Impurity 66
Canagliflozin Impurity 8 Canagliflozin Impurity 8
Canagliflozin Impurity 16 Canagliflozin Impurity 16
Oseltamivir Impurity 12 Oseltamivir Impurity 12
Oseltamivir Impurity 32 Oseltamivir Impurity 32
Riociguat IMpurtiy E Riociguat IMpurtiy E
Meropenem impurity diastereomer 2 Meropenem impurity diastereomer 2 96035-15-3 C15H19N3O5S
Clindamycin Impurity A Clindamycin Impurity A
Tigecycline Impurity F Tigecycline Impurity F
ethyl (R)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate ethyl (R)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate 110548-06-6 C15H13F2NO4
Indacaterol Impurity 7 Indacaterol Impurity 7 1403389-05-8 C24H30N2O3
tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 1883672-48-7 C29H38ClN7O4
1-cyclopropyl-7-fluoro-6,8-dimethoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 1-cyclopropyl-7-fluoro-6,8-dimethoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid C15H14FNO5
cis-cyclo(Pro-Pro) cis-cyclo(Pro-Pro) 19943-27-2 C10H14N2O2
Ropivacaine-cycle Ropivacaine-cycle 1945965-95-6 C17H24N2O
4-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide 4-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide 181696-12-8 C16H14N2O3S
Bupivacaine  Impurity Bupivacaine Impurity 2125995-27-7 C18H28N2O.ClH
Brexpiprazole  Impurity Brexpiprazole Impurity 2059954-32-2 C17H21Cl2NO2
BDJS-SH 2 BDJS-SH 2 36585-31-6 C12H18N2O2
XMUJPIDSOJTMMS-VTBMCCKRSA-N XMUJPIDSOJTMMS-VTBMCCKRSA-N 212505-49-2 C21H30O3
XLMHAABXFLIUNQ-UHFFFAOYSA-N XLMHAABXFLIUNQ-UHFFFAOYSA-N 368451-15-4 C24H26O3
NMEICKDXQPVPKK-UHFFFAOYSA-N NMEICKDXQPVPKK-UHFFFAOYSA-N 120244-82-8 C16H19ClN2O
4-Methylpiperazine-1-carbonyl chloride 4-Methylpiperazine-1-carbonyl chloride 39539-66-7 C6H11ClN2O
Epoxy Exemestane (6-Beta Isomer) Epoxy Exemestane (6-Beta Isomer) 152764-31-3 C20H24O3
AFTMPFJWAIDLME-QWHCGFSZSA-N AFTMPFJWAIDLME-QWHCGFSZSA-N 1808087-53-7 C15H19N3O3S
6-Cyclopropyl-10-fluorobenzo[k]phenanthridine 6-Cyclopropyl-10-fluorobenzo[k]phenanthridine 1187966-95-5 C20H14FN
4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide 4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide 1855006-12-0 C20H18FN5O3
2,2'-((piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene))bis(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one) 2,2'-((piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene))bis(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one) 1255919-03-9 C38H46N10O8S2
Bortezomib Impurity P Bortezomib Impurity P
Esmolol impurity A Esmolol impurity A
(5-(4-fluorophenyl)thiophen-2-yl)(5-iodo-2-methylphenyl)methanol (5-(4-fluorophenyl)thiophen-2-yl)(5-iodo-2-methylphenyl)methanol 1818268-45-9 C18H14FIOS
2-propyl-1H-indene-1,3(2H)-dione 2-propyl-1H-indene-1,3(2H)-dione 14570-43-5 C12H12O2
GLORIOSINE GLORIOSINE 7411-12-3 C21H23NO6
Labetalone hydrochloride Labetalone hydrochloride 96441-14-4 C19H22N2O3.ClH
6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-
7,9-dimethyl-7,9-dihydro-8H-purin-8-one 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)- 7,9-dimethyl-7,9-dihydro-8H-purin-8-one 1361569-23-4 C20H17FN8O
5-(1-amino-2-(methylsulfonyl)ethyl)-2-methoxyphenol 5-(1-amino-2-(methylsulfonyl)ethyl)-2-methoxyphenol 2169153-70-0 C10H15NO4S
Bendamustine Impurity 14 Bendamustine Impurity 14
Canagliflozin Impurity 28 Canagliflozin Impurity 28
Edoxaban Impurity 24 (1S,2S,4R) Edoxaban Impurity 24 (1S,2S,4R) 2024614-21-7 C21H30ClN5O5
Edoxaban Impurity 39 Edoxaban Impurity 39 2081883-55-6 C14H27N3O3
Ezetimibe Impurity 34 Ezetimibe Impurity 34 2280081-69-6 C20H21NO4
Linagliptin Impurity 33 Linagliptin Impurity 33 2443735-53-1 C38H42N10O4
Milrinone Impurity 15 Milrinone Impurity 15 156033-07-7 C12H9N3O2
Milrinone Impurity 6 Milrinone Impurity 6
Fasudil iMpurity A Fasudil iMpurity A
Pantoprazole Impurity 2 Pantoprazole Impurity 2
rac-Valsartan EP Impurity B rac-Valsartan EP Impurity B 1894176-44-3 C31H35N5O3
Sitafloxacin Dechloro Impurity Sitafloxacin Dechloro Impurity
Ticagrelor Related Compound 85 Ticagrelor Related Compound 85 1628340-74-8 C28H34F2N6O5S
Valsartan Impurity 12 Valsartan Impurity 12 1189547-11-2 C11H21NO3
Vonoprazan Impurity 17 Vonoprazan Impurity 17
Avibactam Impurity B Avibactam Impurity B
Brexpiprazole Impurity L Brexpiprazole Impurity L
Cefaclor Impurity 4 Cefaclor Impurity 4
Linagliptin Impurity 38 Linagliptin Impurity 38 1979144-52-9 C20H17ClN6O2
Pidotimod Impurity N Pidotimod Impurity N
Pitavastatin (3S,5S)-Isomer Ethyl Ester Pitavastatin (3S,5S)-Isomer Ethyl Ester
Pramipexole Impurity 3 Pramipexole Impurity 3
Rupatadine Impurity A Rupatadine Impurity A
Sulpiride Impurity 2 Sulpiride Impurity 2
Tenofovir Impurity 55 Tenofovir Impurity 55
Voriconazole Impurity F Voriconazole Impurity F
MEDICARPIN-3-O-GLUCOSIDE MEDICARPIN-3-O-GLUCOSIDE 52766-70-8 C22H24O9
Atorvastatin Impurity F Atorvastatin Impurity F 1371615-56-3 C66H68CaF2N4O10
Ambroxol  Impurity 8(Ambroxol  Impurity M) Ambroxol Impurity 8(Ambroxol Impurity M) 1445719-53-8 C13H16Br2N2O
Cefdinir impurity PQ mixture Cefdinir impurity PQ mixture
Loratadine Impurity 16 Loratadine Impurity 16 C22H23ClN2O2
Meptazinol BP Impurity D Meptazinol BP Impurity D 1883577-02-3 C30H44N2O
Prasugrel Impurity 12 Prasugrel Impurity 12
Pregabalin Impurity 16 Pregabalin Impurity 16
PSI-7977-13C-d3 PSI-7977-13C-d3 2070009-25-3 C2113CH26D3FN3O9P
7-Hydroxy Alosetron 7-Hydroxy Alosetron 863485-44-3 C17H18N4O2
Dolutegravir 2-Desfluoro Impurity Dolutegravir 2-Desfluoro Impurity 1863916-88-4 C20H20FN3O5
Moxifloxacin Impurity 46 Moxifloxacin Impurity 46 1932499-97-2 C8H16N2
Posaconazole Impurity 43 Posaconazole Impurity 43 1428118-40-4 C13H20N2O2
Empagliflozin Impurity 32 Empagliflozin Impurity 32 1620758-25-9 C24H29ClO8
Sugammadex Impurity 16 Sugammadex Impurity 16 2412952-97-5 C69H108BrNaO46S7
1,1'-(1,4,8,11-tetraazacyclotetradecane-1,11-diyl)bis(2,2,2- trifluoroethan-1-one) dihydrochloride 1,1'-(1,4,8,11-tetraazacyclotetradecane-1,11-diyl)bis(2,2,2- trifluoroethan-1-one) dihydrochloride C14H24Cl2F6N4O2
9-fluoro-6,7-dihydro-5-methyl-1-oxo-8-(4-oxo-1,2,3,4-tetrahydro-1-pyridyl)-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid 9-fluoro-6,7-dihydro-5-methyl-1-oxo-8-(4-oxo-1,2,3,4-tetrahydro-1-pyridyl)-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid 130539-72-9 C19H17FN2O4
Clopidogrel Clopidogrel 444728-15-8 C15H15ClN2OS
(3R,5S)-5-((S)-8-fluoro-4-isopropyl-2-(N-methylmethyl sulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5- dihydroxypentanoate calcium(II) (3R,5S)-5-((S)-8-fluoro-4-isopropyl-2-(N-methylmethyl sulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5- dihydroxypentanoate calcium(II) 854898-50-3 C44H54CaF2N6O12S2
Arbidol Impurity I Arbidol Impurity I 153633-10-4 C22H24Br2N2O3S
Palonosetron Impurity 9 Palonosetron Impurity 9 2216755-75-6 C18H24N2O
Zopiclone Impurity 12 Zopiclone Impurity 12
Selexipag impurity Selexipag impurity
2-(3-formyl-4-isobutoxyphenyl)-N,N,4-trimethylthiazole- 5-carboxamide 2-(3-formyl-4-isobutoxyphenyl)-N,N,4-trimethylthiazole- 5-carboxamide 1380049-42-2 C18H22N2O3S
Benidipine Impurity V Benidipine Impurity V
Cefazolin USP Impurity L-△2 Cefazolin USP Impurity L-△2
Fluconazole Impurity M Fluconazole Impurity M C13H12F2N6O
Nicorandil Impurity 14 Nicorandil Impurity 14
Ticagrelor Impurity 64 Ticagrelor Impurity 64
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