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ChemicalBook >> CAS DataBase List >> UNC2250

UNC2250

UNC2250 price.
  • $32 - $2565
  • Product name: UNC2250
  • CAS: 1493694-70-4
  • MF: C24H36N6O2
  • MW: 440.58
  • EINECS:
  • MDL Number:MFCD27992060
  • Synonyms:(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;UNC2250;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol UNC2250;CS-1346;UNC2250(UNC 2250);4-[[2-(butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-ol;Cyclohexanol, 4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-, trans-
22 prices
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  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberY1868
  • Product descriptionUNC2250
  • Packaging1g
  • Price$2565
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA202271
  • Product descriptiontrans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol 98+%
  • Packaging100mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA202271
  • Product descriptiontrans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol 98+%
  • Packaging250mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA202271
  • Product descriptiontrans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol 98+%
  • Packaging1g
  • Price$1125
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2060
  • Product descriptionUNC2250
  • Packaging5mg
  • Price$71
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2060
  • Product descriptionUNC2250
  • Packaging50mg
  • Price$419
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17703
  • Product descriptionUNC2250 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17703
  • Product descriptionUNC2250 ≥98%
  • Packaging5mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17703
  • Product descriptionUNC2250 ≥98%
  • Packaging10mg
  • Price$184
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17703
  • Product descriptionUNC2250 ≥98%
  • Packaging50mg
  • Price$606
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM116473
  • Product descriptiontrans-4-[[2-(Butylamino)-5-[5-(morpholinomethyl)-2-pyridyl]-4-pyrimidinyl]amino]cyclohexanol 98%
  • Packaging50mg
  • Price$361
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2318
  • Product descriptionUNC2250 99.96%
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2318
  • Product descriptionUNC2250 99.96%
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2318
  • Product descriptionUNC2250 99.96%
  • Packaging50mg
  • Price$440
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2318
  • Product descriptionUNC2250 99.96%
  • Packaging100mg
  • Price$740
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003358
  • Product descriptionUNC2250 98+%
  • Packaging50mg
  • Price$440
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y1868 UNC2250 1g $2565 2021-12-16 Buy
Ambeed A202271 trans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol 98+% 100mg $300 2021-12-16 Buy
Ambeed A202271 trans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol 98+% 250mg $450 2021-12-16 Buy
Ambeed A202271 trans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol 98+% 1g $1125 2021-12-16 Buy
ApexBio Technology B2060 UNC2250 5mg $71 2021-12-16 Buy
ApexBio Technology B2060 UNC2250 50mg $419 2021-12-16 Buy
Cayman Chemical 17703 UNC2250 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 17703 UNC2250 ≥98% 5mg $109 2024-03-01 Buy
Cayman Chemical 17703 UNC2250 ≥98% 10mg $184 2024-03-01 Buy
Cayman Chemical 17703 UNC2250 ≥98% 50mg $606 2024-03-01 Buy
Chemenu CM116473 trans-4-[[2-(Butylamino)-5-[5-(morpholinomethyl)-2-pyridyl]-4-pyrimidinyl]amino]cyclohexanol 98% 50mg $361 2021-12-16 Buy
ChemScene CS-2318 UNC2250 99.96% 5mg $70 2021-12-16 Buy
ChemScene CS-2318 UNC2250 99.96% 10mg $120 2021-12-16 Buy
ChemScene CS-2318 UNC2250 99.96% 50mg $440 2021-12-16 Buy
ChemScene CS-2318 UNC2250 99.96% 100mg $740 2021-12-16 Buy
Crysdot CD31003358 UNC2250 98+% 50mg $440 2021-12-16 Buy

Properties

Melting point :207-210oC
Boiling point :657.4±65.0 °C(Predicted)
Density :1.224±0.06 g/cm3(Predicted)
storage temp. :Refrigerator, under inert atmosphere
solubility :Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form :Solid
pka :15.02±0.40(Predicted)
color :Pale Yellow to Yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Tyro3, Axl, and Mer are members of the TAM family of receptor tyrosine kinases that have signaling roles in normal and malignant cells. UNC2250 is an inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC50 value of 9.8 nM. It is selective for Mer over a panel of both tyrosine and serine-threonine kinases, including Tyro3 and Axl. UNC2250 also inhibits ligand-dependent phosphorylation of a chimeric EGFR-Mer protein and blocks colony formation in soft agar cultures of BT-12 rhabdoid tumor and Colo699 NSCLC cell lines. UNC2250 displays good pharmacokinetic properties in mice following intravenous or oral administration.

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