3,4-Dihydroxyphenylessigsure
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- CAS-Nr.
- 102-32-9
- Bezeichnung:
- 3,4-Dihydroxyphenylessigsure
- Englisch Name:
- 3,4-Dihydroxyphenylacetic acid
- Synonyma:
- 2-(3,4-dihydroxyphenyl)acetic acid;DOPAC;3,4-Dihydroxybenzeneacetic acid;3,4-DihydroxyphenyL;HOMOPROTOCATECHUIC ACID;Dihydroxyphenylacetic acid;N,N-DIMETHYL-P-PHENYLENEDIAMINE SULFATE;ba2773;Ba 2773;dopaceticacid
- CBNumber:
- CB7358779
- Summenformel:
- C8H8O4
- Molgewicht:
- 168.15
- MOL-Datei:
- 102-32-9.mol
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3,4-Dihydroxyphenylessigsure Eigenschaften
- Schmelzpunkt:
- 127-130 °C (lit.)
- Siedepunkt:
- 257.07°C (rough estimate)
- Dichte
- 1.3037 (rough estimate)
- Brechungsindex
- 1.5090 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- water: soluble50mg/mL, clear, almost colorless
- pka
- 4.42±0.10(Predicted)
- Aggregatzustand
- Powder, Crystals or Lumps
- Farbe
- White to off-white
- Wasserl?slichkeit
- Soluble in water and methanol.
- BRN
- 2211017
- InChI
- InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)
- InChIKey
- CFFZDZCDUFSOFZ-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=C(O)C(O)=C1
- LogP
- 0.980
- CAS Datenbank
- 102-32-9(CAS DataBase Reference)
- NIST chemische Informationen
- Acetic acid, (3,4-dihydroxyphenyl)-,(102-32-9)
- EPA chemische Informationen
- 3,4-Dihydroxyphenylacetic acid (102-32-9)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
AH0590000 |
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| F |
10-23 |
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| HS Code |
29182900 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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3,4-Dihydroxyphenylessigsure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine. Dopamine can be metabolized into one of three substances. One such substance is DOPAC. Another is 3-methoxytyramine (3-MT). Both of these substances are degraded to form homovanillic acid (HVA). Both degradations involve the enzymes monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT), albeit in reverse order: MAO catalyzes dopamine to DOPAC, and COMT catalyzes DOPAC to HVA; whereas COMT catalyzes dopamine to 3-MT and MAO catalyzes 3-MT to HVA. The third metabolic end-product of dopamine is norepinephrine (noradrenaline).
DOPAC can be oxidized by hydrogen peroxide, leading to the formation of toxic metabolites which destroy dopamine storage vesicles in the substantia nigra. This may contribute to the failure of levodopa treatment of Parkinson's disease. A MAO-B inhibitor such as selegiline or rasagiline can prevent this from happening.
wikipedia
Chemische Eigenschaften
beige to light brown crystalline powder
Verwenden
3,4-Dihydroxyphenylacetic Acid is a metabolite of Dopamine (D533782).
Allgemeine Beschreibung
3,4-dihydroxyphenylacetic acid (DOPAC) is a normal constituent of rat brain tissue. A mass fragmentographic method for determination of DOPAC in rat brain tissue has been described. It is major metabolite of dopamine (DA). The voltammetric reduction of DOPAC has been studied at a glassy carbon electrode modified with single-wall carbon nanotubes (SWNTs). Semi-automatic fluorometric assay technique for DOPAC has been reported.
3,4-Dihydroxyphenylessigsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3,4-Dihydroxyphenylessigsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 312)Lieferanten
102-32-9(3,4-Dihydroxyphenylessigsure)Verwandte Suche:
Ethyl-4-hydroxy-3-methoxyphenylacetat
4-Hydroxy-3-methoxyphenylessigsure
(±)-3,4-Dihydroxyphenylglykolsure
2-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)essigsure
3,4,5-Trimethoxyphenylessigsure
Ethyl-3,4-dimethoxyphenylacetat
Methyl-3,4-dimethoxyphenylacetat
Benzo-1,3-dioxol-5-essigsure
3,4-Diethoxyphenylessigsure
4-Hydroxy-3,5-dimethoxyphenylessigsure
(2,3,4-Trimethoxyphenyl)essigsure
3,4-Dihydroxyphenylessigsure
α-Hydroxy-1,3-benzodioxol-5-essigsure
4-Ethoxy-3-methoxyphenylessigsure
N,N-Dimethylbenzol-1,4-diammoniumsulfat
(2,5-Dihydroxyphenyl)essigsure
Methyl-4-hydroxy-3-methoxyphenylacetat
1,4-benzodioxan-6-ylessigsaeure
- Ba 2773
- DIHYDROXYPHENYLACETIC ACID, 3,4-(RG)
- Dopac/(3,4-dihydroxyphenyl)-aceticaci
- Hypoxanthine DisodiuM
- (3,4-dihydroxyphenyl)-aceticaci
- 3,4-dihydroxy-benzeneaceticaci
- 3,4-dihydroxybenzeneaceticacid
- 3,4-Dihydroxyphenylacetic acid, 98+%
- 3,4-Dihydroxyphenylcaetic acid
- 3,4-DIHYDROXYPHENYLACETIC ACID, 97+%
- DOPAC, Homoprotocatechuic acid
- ba2773
- Benzeneacetic acid, 3,4-dihydroxy-
- dihydroxyphenylaceticacid
- Dopacetic acid
- dopaceticacid
- PYROCATECHOL-4-ACETIC ACID
- CATECHOL-4-ACETIC ACID
- 4-CARBOXYMETHYLPYROCATECHOL
- 4-CARBOXYMETHYLCATECHOL
- 3,4-DIHYDROXYPHENYLACETIC ACID
- Catechol-p-acetic acid
- 4-Carboxymethylcatechol
4-Carboxymethylpyrocatechol
Catechol-4-acetic Acid
Homoprotocatechuic Acid
Pyrocatechol-4-acetic Acid
- 3,4-Dihydroxyphenylacetic Acid >
- Mouse 3,4 dihydroxyphenylacetic acid elisa kit
- CAS 102-32-9 3, 4-Dihydroxybenzeneacetic Acid
- 3,4-Dihydroxybenzeneacetic acid
- 2-(3,4-dihydroxyphenyl)acetic acid
- Dihydroxyphenylacetic acid
- N,N-DIMETHYL-P-PHENYLENEDIAMINE SULFATE
- DOPAC
- HOMOPROTOCATECHUIC ACID
- 3,4-DihydroxyphenyL
- Senecionine Impurity 1
- Drotaveraldine Impurity 08
- 3,4-Dihydroxyphenylacetic acid in methanol
- 102-32-9
- HO2C6H3CH2CO2H
- HOHOC6H3CH2COOH
- HO2C6H3CD2COOH
- C8
- Carbonyl Compounds
- Carboxylic Acids
- Building Blocks
- Organic Building Blocks
- buildingblock
- Aromatic Phenylacetic Acids and Derivatives
