530-59-6
中文名稱
芥子酸
英文名稱
4-Hydroxy-3,5-dimethoxycinnamic acid
CAS
530-59-6
EINECS 編號
208-487-3
分子式
C11H12O5
MDL 編號
MFCD00004401
分子量
224.21
MOL 文件
530-59-6.mol
更新日期
2025/04/10 14:29:10
530-59-6 結(jié)構(gòu)式
基本信息
中文別名
咖啡酸反式異構(gòu)體芥子酸
3,5-二甲氧基-4-羥基-反式-苯乙烯酸,
3,5-二甲氧基-4-羥基苯丙烯酸
順13-二十二烯酸
順二十二碳-13-烯酸
3,5-二甲氧基-4-羥基桂皮酸
3,5-二甲氧基-4-羥基肉桂酸
英文別名
3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID, TRANS
3,5-DIMETHOXY-4-HYDROXY-TRANS-CINNAMIC ACID
4-HYDROXY-3,5-DIMETHOXYCINNAMIC ACID
LABOTEST-BB LT00233169
RARECHEM BK HW 0169
SINAPIC ACID
SINAPINIC ACID
(2E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)-2-propenoic acid
2-Propenoic acid, 3-(4-hydroxy-3,5-dimethoxyphenyl)-
3,5-dimethoxy-4-hydroxycinnamicacid(sinapinicacid)
3,5-dimethoxy-4-hydroxycinnamicacid,predominantlytransisomer
trans-3,5-Dimethoxy-4-hydroxycinnamic acid
SINAPINIC ACID, USE TESTED FOR MALDI-TOF MASS SPEC
3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID, 98 %, PREDOMINANTLY TRANS
SINAPIC ACID, PGE. WITH 10 X 10 MG
SINAPIC ACID, MATRIX SUBSTANCE FOR MALDI MS
Sinapinicacid=Sinapicacid
3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapinic acid
3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxycinnamic acid, Sinapic acid
所屬類別
香精與香料：芳香肉桂酸、酯及衍生物物理化學性質(zhì)
外觀性狀白色粉末，溶于三氯甲烷，乙醚，甲醇，來源于菜粕。
熔點203-205 °C (dec.)(lit.)
沸點285.61°C (rough estimate)
密度1.1478 (rough estimate)
折射率1.4720 (estimate)
儲存條件Keep in dark place,Sealed in dry,Room Temperature
溶解度H2O: slightly soluble
酸度系數(shù)(pKa)4.53±0.10(Predicted)
形態(tài)powder
顏色white
氣味 (Odor)at 100.00?%. odorless
水溶解性insoluble
BRN2130006
穩(wěn)定性穩(wěn)定的。與強氧化劑、強堿不相容。易燃。
LogP0.997 (est)
CAS 數(shù)據(jù)庫530-59-6(CAS DataBase Reference)
NIST化學物質(zhì)信息Cinnamic acid, 4-hydroxy-3,5-dimethoxy-(530-59-6)
安全數(shù)據(jù)
警示詞警告
危險性描述H315-H319-H335
危險品標志Xi
危險類別碼R36/37/38
安全說明S26-S36-S37/39
WGK Germany3
Hazard NoteIrritant
海關(guān)編碼29189900
知名試劑公司產(chǎn)品信息
Acros Organics
3，5-二甲氧基-4-羥基肉桂酸3,5-Dimethoxy-4-hydroxycinnamic acid, predominantly trans isomer, 98%(530-59-6)
Sigma Aldrich
530-59-6(sigmaaldrich)常見問題列表
生物活性
Sinapinic acid (Sinapic acid) 是一種天然的小羥基肉桂酸，屬于苯基丙烷類，通常在MALDI質(zhì)譜中用作基質(zhì)。Sinapinic acid (Sinapic acid) 作為 HDAC 的抑制劑，IC50為2.27 mM，并且還抑制 ACE-1 活性。靶點
| Target | Value |
|
HDAC
() | |
|
ACE1
() |
體外研究
Sinapinic acid acts as an inhibitor of HDAC, with an IC
50
of 2.27 mM. Sinapinic acid also inhibits ACE-I activity.
Sinapinic acid inhibits HDAC activity in HeLa cells, suppresses the growth of HeLa and HT29 cells with IC
50
s of 0.91 ± 0.02 mM and 1.6?±?0.02 mM at 72 h, respectively, induces apoptosis of these cancer cells.
體內(nèi)研究
Sinapinic acid (5 or 25 mg/kg, p.o. daily for 4 weeks) increases the serum estradiol concentration; decreases insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affects the parameters of antioxidant abilities (reduces glutathione, superoxide dismutase) and oxidative damage in rats.