34391-04-3
中文名稱
左旋沙丁胺醇
英文名稱
Salbutamol
CAS
34391-04-3
分子式
C13H21NO3
MDL 編號
MFCD00869868
分子量
239.31
MOL 文件
34391-04-3.mol
更新日期
2023/02/10 16:49:10
34391-04-3 結(jié)構式
基本信息
中文別名
左旋沙丁胺醇左旋沙丁胺醇鹽酸鹽
4-[2-(叔丁氨基)-1-羥乙基]-2-(羥甲基)苯酚
英文別名
(L)-ALBUTEROLLEVALBUTEROL
LEVALBUTEROL HCL
R-SALBUTAMOL HCL
(-)-alpha(sup1)-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedime
1,3-benzenedimethanol,alpha(sup1)-(((1,1-dimethylethyl)amino)methyl)-4-hydrox
alpha’-diol,alpha(sup1)-((tert-butylamino)methyl)-4-hydroxy-m-xylene-alph
r-albuterol
Levalbutreol
2-(hydroxymethyl)-4-[1-hydroxy-2-(tert-butylamino)ethyl]phenol
LEVOSALBUTEROLHCL
1,3-Benzenedimethanol, a1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (a1R)- (9CI)
1,3-Benzenedimethanol, a1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (R)-
Levosalbutamol
m-Xylene-a,a'-diol, a1-[(tert-butylamino)methyl]-4-hydroxy-, (R)-(-)- (8CI)
2-(hydroxymethyl)-4-[(1R)-1-hydroxy-2-(tert-butylamino)ethyl]phenol
4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
Salbutamol
(R)-1-(4-Hydroxy-3-hydroxymethylphenyl)-2-(1,1-dimethylethylamino)ethanol
(R)-1-(4-Hydroxy-3-hydroxymethylphenyl)-2-tert-butylaminoethanol
所屬類別
有機原料：氨基化合物物理化學性質(zhì)
沸點433.5±40.0 °C(Predicted)
密度1.152±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)9.99±0.31(Predicted)
CAS 數(shù)據(jù)庫34391-04-3(CAS DataBase Reference)
常見問題列表
生物活性
Levalbuterol ((R)-Albuterol; (R)-Salbutamol) 是短效 β2-腎上腺素受體 (β2-adrenergic receptor) 激動劑和 Salbutamol 的活性 R 型對映異構體。Levalbuterol 是一種比 Salbutamol 更有效的支氣管擴張試劑，可用于哮喘和慢性阻塞性肺疾病 (COPD) 的研究。體外研究
Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2 expression in airway epithelial cells.Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line.
RT-PCR
| Cell Line: | Murine Club (MTCC) cells |
| Concentration: | 10 μM |
| Incubation Time: | 24 hours |
| Result: | Increased 11β-HSD1 mRNA expression selectively. |
體內(nèi)研究
Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE.
| Animal Model: | C57BL/6 female mice?with a pulmonary allergic model |
| Dosage: | 1 mg/kg |
| Administration: | Subcutaneous injection; 1 mg/kg; 14 days |
| Result: | Decreased pulmonary inflammation after OVA sensitization. |