148819-94-7
148819-94-7 結構式
基本信息
2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE, POTASSIUM SALT
2-(4-CARBOXYPHENYL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-1H-IMIDAZOL-1-YLOXY-3-OXIDE POTASSIUM
2-(4-CARBOXYPHENYL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-1H-IMIDAZOLYL-1-OXY-3-OXIDE, POTASSIUM SALT
2-(4-CARBOXYPHENYL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL, POTASSIUM SALT
CARBOXY-PTIO
CARBOXY-PTIO POTASSIUM
CARBOXY-PTIO, POTASSIUM SALT
CARBOXY-PTIO POTASSIUM (2-(4-CARBOXYPHEN YL)-4,4,5,5-TETRAMETHYLIM
2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt, 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt
物理化學性質
常見問題列表
Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by physalin A treatment, but no change is observed in Carboxy-PTIO treatment alone.Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) reduces physalin A-induced cleavage of procaspase-3 and PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei.Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR and p-mTOR levels induced by physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells .
Western Blot Analysis
| Cell Line: | A375-S2 cells |
| Concentration: | 200 μM |
| Incubation Time: | 1 h prior to physalin A; 24 hours |
| Result: | Diminished physalin A-induced procaspase-3 and PARP cleavage. |
Carboxy-PTIO (intravenous?injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min) treatment improves the hypotension, renal dysfunction and survival rate in Lps-treated rats. But it does not affect each parameter in naomal rats.
| Animal Model: | SD rats |
| Dosage: | 0.056-1.70 mg/kg/min |
| Administration: | Intravenous?injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min |
| Result: | Exhibited a potent therapeutic value in endotoxin shock through the direct scavenging action against NO. |