ETHYL THIOPHENE-2-GLYOXYLATE synthesis
- Product Name:ETHYL THIOPHENE-2-GLYOXYLATE
- CAS Number:4075-58-5
- Molecular formula:C8H8O3S
- Molecular Weight:184.21
33898-90-7
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$8.00/1g
64-17-5
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$10.00/50g
4075-58-5
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$19.00/1g
Yield: 82%
Reaction Conditions:
with [bis(acetoxy)iodo]benzene in dichloromethane for 2 h;Reflux;
Steps:
Ethyl 2-thienylglyoxylate 3m
General procedure: β-Oxo-benzenepropanenitrile 1(1.0 mmol),PIDA (2.2 mmol) were dissolved in EtOH (8 mL) and stirred under refluxing for 0.5h. After the reaction was completed (monitored by TLC), thereaction mixture was concentrated under vacuum. The residue was purified by chromatographyon silica gel (20:1 petroleum ether/EtOAc) to give the product 3a-o .Thesolvent for the synthesis of 3o was MeOH.
References:
Xie, Yuanyuan;Liu, Jiwei;Huang, Yingyi;Yao, Lixia [Tetrahedron Letters,2015,vol. 56,# 24,p. 3793 - 3795] Location in patent:supporting information
5713-61-1
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95-92-1
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4075-58-5
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$19.00/1g
1003-09-4
480 suppliers
$10.00/25g
95-92-1
418 suppliers
$5.00/5 g
4075-58-5
106 suppliers
$19.00/1g
