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ChemicalBook CAS DataBase List Ethylthiophene-2-carboximidoatehydrochloride
54610-52-5

Ethylthiophene-2-carboximidoatehydrochloride synthesis

2synthesis methods
-

Yield:54610-52-5 16.3 g (37%)

Reaction Conditions:

with hydrogenchloride in ethanol;

Steps:

R.19.1 Synthesis of [5-benzyloxycarbonylamino-6-oxo-2-(2-thienyl)-1,6-dihydro-1-pyrimidinyl]acetic acid.

(1) Ethyl 2-thiophenecarboximidate hydrochloride was synthesised in the same manner as in Reference Example 2. That is, 2-thiophenecarbonitrile (25.2 g, 0.231 mol) was treated with hydrogen chloride in ethanol (250 mL) to give 16.3 g (37%) of the target compound as colorless crystals.

References:

US5948785,1999,A

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