ChemicalBook CAS DataBase List 2-Thiopheneacetic acid

2-Thiopheneacetic acid synthesis

12synthesis methods

Product Name:2-Thiopheneacetic acid
CAS Number:1918-77-0
Molecular formula:C6H6O2S
Molecular Weight:142.18

5402-55-1 Synthesis

5402-55-1
492 suppliers
$5.00/5g

1918-77-0
416 suppliers
$5.00/100mg

Yield:1918-77-0 96.5%

Reaction Conditions:

with oxygen;triethylamine at 80; for 15 h;Reagent/catalyst;Temperature;

Steps:

1.1; 2.1; 3.1; 4.1; 5.1; 6.1; 7.1; 1-2 1. Preparation of 2-thiophene acetic acid
Dissolve 128 grams of 2-thiophene ethanol in 0.5 liter of anisole, stir and raise the temperature to 80°C,Add 5 grams of catalyst bentonite,60 grams of co-catalyst triethylamine,64 grams of dry oxygen is introduced,The aeration time is 5 hours, and the reaction is stirred at 80°C for 10 hours.After cooling down, it is separated and purified2-thiophene acetic acid was obtained, and the separation method was the same as that in Example 1.The yield was 96.5percent.The purity is higher than 99.5percent.

References:

Anda Haina Bell Chemical Co., Ltd.;Guo Qishuang;Liu Jing;Zhang Ming;Guo Wanbao;Wang Libao CN111560005, 2020, A Location in patent:Paragraph 0034-0037; 0041-0044; 0046-0049; 0051-0054; 0056

FullText