Ethyl 4-bromobenzoate synthesis
- Product Name:Ethyl 4-bromobenzoate
- CAS Number:5798-75-4
- Molecular formula:C9H9BrO2
- Molecular Weight:229.07
Yield:5798-75-4 90%
Reaction Conditions:
with 3-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methyl-1-(2,6-diisopropylphenyl)-1H-imidazol-3-ium bis(trifluoromethanesulfonimide) salt;caesium carbonate in toluene at 60; for 3 h;
Steps:
2.6 6) ethyl 4-bromobenzoatePreparation:
Accurately weigh 0.1mol 4-bromobenzaldehyde,Add to 500mL round bottom flask, then add 0.5mol ethanol,0.005mol 1- (2,6-diisopropyl) phenyl-3- (7,7-dimethyl-2-oxobicyclo [2.2.1] hept-1-yl) methyl-1H-imidazole -3- onium bis (trifluoromethanesulfonimide) salt,0.05mol of cesium carbonate, 150mL of toluene, put on an air balloon, and stir at 60 ° C for 3h.After the reaction, the reaction solution was cooled to room temperature, washed with saturated brine to neutrality, concentrated under reduced pressure, and subjected to column chromatography to obtain ethyl 4-bromobenzoate.The yield was 90%.
References:
Nanjing Forestry University;Wang Shifa;Bian Tiancen;Zhao Yuxun;Xu Xu;Yang Yiqin;Gu Wen CN110272344, 2019, A Location in patent:Paragraph 0060; 0067
34421-94-8
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$51.70/25g
5798-75-4
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$6.00/5g
