ETHYL 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLATE synthesis
- Product Name:ETHYL 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLATE
- CAS Number:402567-86-6
- Molecular formula:C18H15NO2S
- Molecular Weight:309.38
![Benzenepropanoic acid, α-[[(4-methylphenyl)sulfonyl]oxy]-β-oxo-, ethyl ester](/CAS/20210305/GIF/81447-37-2.gif)
Yield:402567-86-6 85%
Reaction Conditions:
in N,N-dimethyl-formamide at 60;Inert atmosphere;
Steps:
1 Ethyl 2,4-diphenylthiazole-5-carboxylate
To a flame dried flask cooled under argon was added ethyl 3-oxo-3-phenyl-2-(tosyloxy)propanoate (0.1 grams, 0.276 mmol), benzothioamide (0.038 grams, 0.28 mmol, purchased from Aldrich) and 1 mL of DMF (anhydrous, purchased from Fisher Scientific). The stirring solution was then heated to 60° C. where the reaction remained until it had gone to completion. It was then cooled to room temperature and concentrated. Chromatography using silica gel (hexanes, ethyl acetate (95:5) afforded the desired ethyl 2,4-diphe- nylthiazole-5-carboxylate in 85% yield.
References:
US2014/275178,2014,A1 Location in patent:Paragraph 0071; 0072
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