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ChemicalBook CAS DataBase List 8-Aminooctanoic acid
1002-57-9

8-Aminooctanoic acid synthesis

7synthesis methods
8-Aminooctanoic acid is involved in the preparation of lactams using enzyme catalyzed aminolysis.  It was prepared from methyl 8-aminooctanoate with 10% Pd/C by stirring in water for 2h at  177°C.
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Yield:1002-57-9 95%

Reaction Conditions:

in water

Steps:

STAGE FOUR
STAGE FOUR A mixture of 13 grams of methyl 8-aminooctanoate (68 mmoles) and 200 ml. of water (11.1 moles) were heated for 2 hours at 177°C. under nitrogen. Upon cooling, the contents were removed and water stripped under reduced pressure. The residue (10.3 grams, 95 percent yield) was identified by infrared and nuclear magnetic resonance to contain 8-aminooctanoic acid.

References:

Texaco Inc. US3933873, 1976, A

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