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ChemicalBook CAS DataBase List Citric acid
77-92-9

Citric acid synthesis

8synthesis methods
By mycological fermentation using molasses and strains of Aspergillus niger; from citrus juices and pineapple wastes
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Yield:77-92-9 85%

Reaction Conditions:

Stage #1: 3,4-dioxo-adipic acidwith N-benzyl-trimethylammonium hydroxide in water at 45; for 6 h;
Stage #2: with hydrogenchloride in water; pH=2.9;

Steps:

9

Example 9 Synthesis of 2-Hydroxypropane-1,2,3-Tricarboxylic Acid A solution of 3,4-dioxohexanedioic acid (0.1 mol) in Triton B (0.2 mol in 5 ml of water) was heated at 45° C. for 6 hrs. The mixture was cooled and acidified with 30% hydrochloric acid up to pH 2.9. The solid filtered and wash with cold water to obtained 2-hydroxypropane-1,2,3-tricarboxylic acid in 85% yield.

References:

US2010/249451,2010,A1 Location in patent:Page/Page column 3-4

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