5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid synthesis
- Product Name:5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid
- CAS Number:74936-72-4
- Molecular formula:C16H16N2O6
- Molecular Weight:332.31
75130-24-4
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74936-72-4
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Yield:74936-72-4 86.8%
Reaction Conditions:
with water;sodium hydroxide at 20;Reagent/catalyst;
Steps:
1.3; 2.3
(3) Intermediate 2 (1800g),750 g of a 3% aqueous sodium hydroxide solution was added to the reaction.The reaction is carried out at room temperature for 2 to 3 hours; and then extracted with 10000 g of dichloromethane;The aqueous phase was acidified to pH = 1-2 with 10% hydrochloric acid. Filtered, dried,It has a pale yellow solid. The obtained solid was recrystallized from methanol to give Intermediate 3 (1346 g).The yield was 86.8%.
References:
CN109111431,2019,A Location in patent:Paragraph 0042; 0046; 0056; 0060
21881-77-6
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74936-72-4
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21881-77-6
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7440-44-0
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74936-72-4
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541-50-4
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99-61-6
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14205-39-1
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74936-72-4
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99-61-6
647 suppliers
$5.00/10g
74936-72-4
256 suppliers
$15.00/5g