天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Nicardipine
55985-32-5

Nicardipine synthesis

2synthesis methods
Nicardipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl-2-[(methylphenylmethyl)- amino]ethyl ester 3,5-pirididincarboxylic acid (19.3.7), is synthesized in a manner analogous to the synthesis of nifedipine, the only difference being that in the Hantsch synthesis, two different β-dicarbonyl compounds are used simultaneously with o-nitrobenzaldehyde. During this, one of these in the enamine form of acetoacetic ester is simultaneously used as an amine component. A heterocyclization reaction is accomplished by reacting, the methyl ester of β-aminocrotonic acid with the 2-methyl-2-benzylaminoethyl ester of acetoacetic acid.

-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 100 percent / 1.) Et3N; 2.) H2O / tetrahydrofuran / 1.) 1 h; 2.) 0.5 h
2: 77 percent / 8 h / Heating

References:

Ohno;Komatsu;Mizukoshi;Ichihara;Nakamura;Morishima;Sumita [Chemical and Pharmaceutical Bulletin,1986,vol. 34,# 4,p. 1589 - 1606]

Nicardipine Related Search: