ChemicalBook CAS DataBase List Methyl 3-aminocrotonate

Methyl 3-aminocrotonate synthesis

4synthesis methods

Product Name:Methyl 3-aminocrotonate
CAS Number:14205-39-1
Molecular formula:C5H9NO2
Molecular Weight:115.13

3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists.

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14205-39-1
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Yield:14205-39-1 94%

Reaction Conditions:

with ammonia;acetic acidProduct distribution / selectivity;

Steps:

5
Example 5: Process for the preparation of methyl amino crotonate Continuous flow experiment was carried out in a SS316 tubular reactor of 6.35 mm o.d. and 2 m length at 50 ^e C with a residence time of 120 - 160 s without any solvent. The Methyl aceto acetate to ammonia to catalyst (Acetic acid)- volume ratio of 1:3:0.5 yielded 94% methyl amino crotonate from the first crop. No choking of reactor was observed.

References:

COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH;KULKARNI, Amol, Arvind;JOSHI, Ramesh, Anna;JOSHI, Rohini, Ramesh WO2012/147103, 2012, A2 Location in patent:Page/Page column 6-7

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