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ChemicalBook CAS DataBase List Nifedipine
21829-25-4

Nifedipine synthesis

6synthesis methods
Nifedipine, dimethyl ether 1,4-dihydro-2,6-dimethyl-4-(2′-nitrophenyl)-3,5- piridindicarboxylic acid (19.3.16), is synthesized by a Hantsch synthesis from two molecules of a β-dicarbonyl compound—methyl acetoacetate, using as the aldehyde component— 2-nitrobenzaldehyde and ammonia. The sequence of the intermediate stages of synthesis has not been completely established.

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Yield:21829-25-4 95%

Reaction Conditions:

with C23H3BF16N2O;ammonium acetate in toluene at 100; for 10 h;Hantzsch Dihydropyridine Synthesis;

Steps:

61 Preparation 61

In the 100 ml flask is added in a single port 0.01 μM % Lewis acid-base dual function catalyst I (wherein Rf=CF3; R1, R2, R3, R4, R5, R6=F), 0.1 μM O-nitrobenzaldehyde (R7=2 - NO2- Ph), 0.1 μM methyl acetoacetate (R8=Me; R9=Me), 0.1 μM ammonium acetate, 10 ml toluene, the reaction in the 100 °C stirring for 10 hours, TLC tracking reaction to the reaction is complete. The reaction result is: product II (R7=2 - NO2- Ph; R8=Me; R9=Me) of yield of 99%; catalyst system used repeatedly 10 times, its catalytic performance did not decline

References:

CN107141249,2017,A Location in patent:Paragraph 0138; 0139

39562-27-1 Synthesis
METHYL 2-(O-NITROBENZYLIDENE)-ACETOACETATE

39562-27-1
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14205-39-1 Synthesis
Methyl 3-aminocrotonate

14205-39-1
511 suppliers
$6.00/25g

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