天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 7-Hydroxygranisetron
4498-67-3

7-Hydroxygranisetron synthesis

11synthesis methods
-

Yield:4498-67-3 100%

Reaction Conditions:

with sodium hydroxide in hydrogenchloride;water;

Steps:

87.4 (Step 4)

(Step 4) Synthesis of indazole-3-carboxylic acid To methyl 1-acetylindazole-3-carboxylate (22.3 g, 0.10 mol) were added sodium hydroxide (8.18 g, 0.20 mol) and water (640 ml) and the resulting mixture was stirred at 60 to 70?C for 6.5 hours. The reaction mixture was poured in concentrated HCl (30 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give indazole-3-carboxylic acid (17.6 g, 100%) as a pale yellow solid. 1H-NMR (DMSO-d6) δ: 7.29 (m, 1H), 7.44 (m, 1H), 7.65 (d, J=8.6Hz, 1H), 8.10 (d, J=8.1Hz, 1H), 12.96 (broad s, 1H), 13.77 (broad s, 1H).

References:

EP1346982,2003,A1

7-Hydroxygranisetron Related Search: