6-Fluoro-2-oxindole synthesis
- Product Name:6-Fluoro-2-oxindole
- CAS Number:56341-39-0
- Molecular formula:C8H6FNO
- Molecular Weight:151.14
39616-95-0
53 suppliers
inquiry
56341-39-0
171 suppliers
$28.00/250 mg
Yield:56341-39-0 91%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in acetic acid under 2585.81 Torr;
Steps:
IV 6-Fluoro-2-indolinone
With addition of 20 g of palladium on activated carbon (10%), 119 g of 4-fluoro-2-nitrophenylacetic acid (starting material III) are hydrogenated in 600 ml of acetic acid under a hydrogen pressure of 50 psi. The catalyst is filtered off with suction and the solvent is distilled off. The crude product is triturated with 500 ml of petroleum ether, filtered off with suction, washed with water and dried. [0239] Yield: 82.5 g (91% of theory) [0240] Rf value: 0.30 (silica gel, petroleum ether/ethyl acetate 1:1) [0241] C8H6FNO [0242] Mass spectrum: m/z=150 [M-H]-
References:
Boehringer Ingelheim Pharma GmbH & Co. KG US2005/43389, 2005, A1 Location in patent:Page/Page column 19
147124-38-7
14 suppliers
inquiry
56341-39-0
171 suppliers
$28.00/250 mg
350-81-2
58 suppliers
$9.00/5g
56341-39-0
171 suppliers
$28.00/250 mg
147124-35-4
5 suppliers
inquiry
56341-39-0
171 suppliers
$28.00/250 mg
1209007-72-6
31 suppliers
inquiry
56341-39-0
171 suppliers
$28.00/250 mg